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dc.contributor.author
Brosens, Jan J.
dc.contributor.author
Bennett, Phillip R.
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Abrahams, Vikki M.
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Ramhorst, Rosanna Elizabeth
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Coomarasamy, Arri
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Quenby, Siobhan
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Lucas, Emma S.
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McCoy, Rajiv C.
dc.date.available
2023-09-21T14:30:44Z
dc.date.issued
2022-11
dc.identifier.citation
Brosens, Jan J.; Bennett, Phillip R.; Abrahams, Vikki M.; Ramhorst, Rosanna Elizabeth; Coomarasamy, Arri; et al.; Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage; Academic Press Ltd - Elsevier Science Ltd; Seminars In Cell & Developmental Biology; 131; 11-2022; 14-24
dc.identifier.issn
1084-9521
dc.identifier.uri
http://hdl.handle.net/11336/212494
dc.description.abstract
Compared to most mammals, human pregnancy is unusual in that it involves chromosomally diverse embryos, cyclical breakdown and regeneration of the uterine mucosa, and intimate integration of fetal and maternal cells at the uteroplacental interface. Not surprisingly, pregnancy often falters in early gestation. Whether these losses result in clinical miscarriages depends on the origins and impacts of chromosomal errors on fetal development and the ability of the decidualizing endometrium to engage in embryo biosensing and selection. Aneuploidy originating in oocytes during meiosis drives the age-related risk of miscarriage. By contrast, the frequency of endometrial cycles with an impaired decidual response may account for the stepwise increase in miscarriage rates with each pregnancy loss independently of maternal age. Additional physiological mechanisms operate in early gestation to ensure that most failing pregnancies are lost before vascular maternal-fetal connections are established by the end of the first trimester. Here, we summarise how investigations into the mechanisms that cause miscarriage led to new insights into the processes that govern maternal selection of human embryos in early gestation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Ltd - Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ANEUPLOIDY
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DECIDUALIZATION
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EMBRYO
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ENDOMETRIUM
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MISCARRIAGE
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PLACENTA
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SELECTION
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Obstetricia y Ginecología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T22:44:26Z
dc.journal.volume
131
dc.journal.pagination
14-24
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Brosens, Jan J.. University Hospital Coventry; Reino Unido. University of Warwick; Reino Unido
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Fil: Bennett, Phillip R.. Imperial College London; Reino Unido
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Fil: Abrahams, Vikki M.. University of Yale; Estados Unidos
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Fil: Ramhorst, Rosanna Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Coomarasamy, Arri. The University Of Birmingham (tub);
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Fil: Quenby, Siobhan. University of Warwick; Reino Unido. University Hospital Coventry; Reino Unido
dc.description.fil
Fil: Lucas, Emma S.. University of Warwick; Reino Unido
dc.description.fil
Fil: McCoy, Rajiv C.. University Johns Hopkins; Estados Unidos
dc.journal.title
Seminars In Cell & Developmental Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1084952122000155
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.semcdb.2022.01.007
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