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dc.contributor.author
Garbinato, Cristiane
dc.contributor.author
Alves Lima Rezende, Cássia
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dc.contributor.author
Schneider, Sabrina Ester
dc.contributor.author
Pedroso, Jefferson
dc.contributor.author
dos Santos, Aline E.
dc.contributor.author
Petry, Fernanda
dc.contributor.author
Aguiar, Gean Pablo S.
dc.contributor.author
Girardi Müller, Liz
dc.contributor.author
Lanza, Marcelo
dc.contributor.author
Piato, Angelo
dc.contributor.author
Vladimir Oliveira, J.
dc.contributor.author
Siebel, Anna Maria
dc.date.available
2023-09-21T12:38:13Z
dc.date.issued
2021-11
dc.identifier.citation
Garbinato, Cristiane; Alves Lima Rezende, Cássia; Schneider, Sabrina Ester; Pedroso, Jefferson; dos Santos, Aline E.; et al.; Investigation on the Anticonvulsant Potential of Luteolin and Micronized Luteolin in Adult Zebrafish (Danio rerio); Springer/Plenum Publishers; Neurochemical Research; 46; 11; 11-2021; 3025-3034
dc.identifier.issn
0364-3190
dc.identifier.uri
http://hdl.handle.net/11336/212448
dc.description.abstract
Epilepsy affects around 50 million people worldwide, and an important number of patients (30%) fail to respond to any available antiepileptic drug. Previous studies have shown that luteolin presents a promising potential as an anticonvulsant. On the other hand, different studies showed that luteolin does not promote anticonvulsant effects. Therefore, there is a lack of consensus about the use of luteolin for seizure control. Luteolin low bioavailability could be a limiting factor to obtain better results. Attractively, micronization technology has been applied to improve flavonoids bioavailability. Thus, the present study aimed to investigate the effects of luteolin on its raw form and micronized luteolin in a PTZ-induced seizure model in adult zebrafish (Danio rerio). Our results demonstrate that luteolin and micronized luteolin did not block PTZ-induced seizures in adult zebrafish. Also, luteolin and micronized luteolin did not provoke behavioral changes. Finally, our results show that 24 h after seizure occurrence, no changes were detected for p70S6Kb, interleukin 1β, and caspase-3 transcript levels. Altogether, we failed to observe an anticonvulsant potential of luteolin in adult zebrafish, even in its micronized form. However, we recommend new studies to investigate luteolin benefits in epilepsy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer/Plenum Publishers
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
EPILEPSY
dc.subject
LUTEOLIN
dc.subject
MICRONIZATION
dc.subject
SEIZURE
dc.subject
ZEBRAFISH
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Investigation on the Anticonvulsant Potential of Luteolin and Micronized Luteolin in Adult Zebrafish (Danio rerio)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-09-20T17:52:03Z
dc.journal.volume
46
dc.journal.number
11
dc.journal.pagination
3025-3034
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Garbinato, Cristiane. No especifíca;
dc.description.fil
Fil: Alves Lima Rezende, Cássia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; Argentina
dc.description.fil
Fil: Schneider, Sabrina Ester. No especifíca;
dc.description.fil
Fil: Pedroso, Jefferson. No especifíca;
dc.description.fil
Fil: dos Santos, Aline E.. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Petry, Fernanda. No especifíca;
dc.description.fil
Fil: Aguiar, Gean Pablo S.. No especifíca;
dc.description.fil
Fil: Girardi Müller, Liz. No especifíca;
dc.description.fil
Fil: Lanza, Marcelo. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Piato, Angelo. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Vladimir Oliveira, J.. Universidade Federal de Santa Catarina; Brasil
dc.description.fil
Fil: Siebel, Anna Maria. No especifíca;
dc.journal.title
Neurochemical Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11064-021-03409-8
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