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dc.contributor.author
Martinez, Valeria Romina
dc.contributor.author
Ferrer, Evelina Gloria
dc.contributor.author
Williams, Patricia Ana María
dc.date.available
2023-09-20T18:32:28Z
dc.date.issued
2021-11
dc.identifier.citation
Martinez, Valeria Romina; Ferrer, Evelina Gloria; Williams, Patricia Ana María; Candesartan, losartan and valsartan Zn(II) complexes interactions with bovine serum albumin; Future Science; Future Medicinal Chemistry; 14; 1; 11-2021; 9-16
dc.identifier.issn
1756-8919
dc.identifier.uri
http://hdl.handle.net/11336/212411
dc.description.abstract
Background: The pharmacological response and the therapeutic efficacy of a drug depends on the interactions with plasma proteins. Methodology: The interaction of bovine serum albumin (BSA) with the metal complexes of antihypertensive drugs, Zn(II)/sartan complexes (candesartan, valsartan and losartan), was investigated using fluorescence quenching determinations at different temperatures. Results: The binding studies of the compounds with BSA showed static quenching and moderate binding with calculated constants in the range of 104 -106 M, indicating potent serum distribution via albumins. In all cases, negative values of free energy are indicative of spontaneous processes and the stabilization of BSA/compound complexes through hydrogen bonding and van der Waals forces. The results for the sartans agree with the reported pharmacokinetics studies. Conclusion: It has been determined that the three sartans and the Zn complexes could be transported and distributed by albumin.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Future Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANGIOTENSIN II RECEPTOR BLOCKERS
dc.subject
BOVINE SERUM ALBUMIN
dc.subject
ZN(II) METAL COMPLEX
dc.title
Candesartan, losartan and valsartan Zn(II) complexes interactions with bovine serum albumin
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-09-14T17:25:13Z
dc.identifier.eissn
1756-8927
dc.journal.volume
14
dc.journal.number
1
dc.journal.pagination
9-16
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Martinez, Valeria Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
dc.description.fil
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
dc.description.fil
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
dc.journal.title
Future Medicinal Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.future-science.com/doi/10.4155/fmc-2021-0216
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.4155/fmc-2021-0216
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