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dc.contributor.author
Pérez Pérez, A.
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Maymo, Julieta Lorena
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Gambino, Yésica Paola
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Guadix, P.
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Dueñas, J. L.
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Varone, Cecilia Laura
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Sánchez Margalet, V.
dc.date.available
2017-07-24T20:44:08Z
dc.date.issued
2013-02
dc.identifier.citation
Pérez Pérez, A.; Maymo, Julieta Lorena; Gambino, Yésica Paola; Guadix, P.; Dueñas, J. L.; et al.; Activated translation signaling in placenta from pregnant women with gestational diabetes mellitus: possible role of leptin; Georg Thieme Verlag Kg; Hormone and Metabolic Research; 45; 6; 2-2013; 436-442
dc.identifier.issn
0018-5043
dc.identifier.uri
http://hdl.handle.net/11336/21237
dc.description.abstract
Placentas from gestational diabetes (GDM) suff er from structural and functional changes including overgrowth. That is why we aimed to study [ 3 H]-leucine incorporation into protein in addition to translation signaling in placenta from GDM. Thus, we investigated the expression of leptin and leptin receptor (LEPR), as well as the activation state of signaling proteins regulating protein synthesis, such as mTOR, S6 Kinase, EIF4E-BP1, EIF4E, and eEF2 by measuring protein phosphorylation by immunoblot. [ 3 H]-Leucine incorporation into protein also was determined in trophoblastic placenta explants from GDM and control pregnancy. We found that leptin and LEPR expression are increased in placentas from GDM and the translation machinery activity as well as [ 3 H]-leucine incorporation into protein were higher in placentas from GDM compared with placentas from control pregnancy. In conclusion, protein synthesis rate is increased in placenta from GDM patients, and this may be due, at least in part, by the activation of translation signaling. The increased expression of leptin and LEPR may contribute to these eff ects. These results may provide a possible mechanism for the previously observed increase in placenta growth in GDM.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Georg Thieme Verlag Kg
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Leptin
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Placenta
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Insulin
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Diabetes
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Activated translation signaling in placenta from pregnant women with gestational diabetes mellitus: possible role of leptin
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-18T15:34:50Z
dc.journal.volume
45
dc.journal.number
6
dc.journal.pagination
436-442
dc.journal.pais
Alemania
dc.description.fil
Fil: Pérez Pérez, A.. Universidad de Sevilla; España
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Fil: Maymo, Julieta Lorena. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
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Fil: Gambino, Yésica Paola. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
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Fil: Guadix, P.. Universidad de Sevilla; España
dc.description.fil
Fil: Dueñas, J. L.. Universidad de Sevilla; España
dc.description.fil
Fil: Varone, Cecilia Laura. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.description.fil
Fil: Sánchez Margalet, V.. Universidad de Sevilla; España
dc.journal.title
Hormone and Metabolic Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1055/s-0032-1333276
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0032-1333276
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