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dc.contributor.author
Citores, Lucía
dc.contributor.author
Ragucci, Sara
dc.contributor.author
Russo, Rosita
dc.contributor.author
Gay, Claudia Carolina
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Chambery, Angela
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Di Maro, Antimo
dc.contributor.author
Iglesias, Rosario
dc.contributor.author
Ferreras, José M.
dc.date.available
2023-09-20T12:47:52Z
dc.date.issued
2023-03
dc.identifier.citation
Citores, Lucía; Ragucci, Sara; Russo, Rosita; Gay, Claudia Carolina; Chambery, Angela; et al.; Structural and functional characterization of the cytotoxic protein ledodin, an atypical ribosome-inactivating protein from shiitake mushroom (Lentinula edodes); John Wiley & Sons; Protein Science; 32; 4; 3-2023; 1-17
dc.identifier.issn
0961-8368
dc.identifier.uri
http://hdl.handle.net/11336/212238
dc.description.abstract
We have purified ledodin, a cytotoxic 22-kDa protein from shiitake mushroom (Lentinula edodes) consisting of a 197 amino acid chain. Ledodin possessed N-glycosylase activity on the sarcin-ricin loop of mammalian 28S rRNA and inhibited protein synthesis. However, it was not active against insect, fungal, and bacterial ribosomes. In vitro and in silico studies suggested that ledodin exhibits a catalytic mechanism like that of DNA glycosylases and plant ribosome-inactivating proteins. Moreover, the sequence and structure of ledodin was not related to any protein of known function, although ledodin-homologous sequences were found in the genome of several species of fungi, some edible, belonging to different orders of the class Agaricomycetes. Therefore, ledodin could be the first of a new family of enzymes widely distributed among this class of basidiomycetes. The interest of these proteins lies both, in the fact that they can be a toxic agent of some edible mushrooms and in their application in medicine and biotechnology.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
PROTEIN SYNTHESIS (INHIBITION)
dc.subject
RIBOSOME-INACTIVATING PROTEIN (RIP)
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RIBOTOXIN
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RRNA N-GLYCOSYLASE
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SHIITAKE (LENTINULA EDODES)
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TOXIN
dc.subject.classification
Bioquímica y Biología Molecular
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Structural and functional characterization of the cytotoxic protein ledodin, an atypical ribosome-inactivating protein from shiitake mushroom (Lentinula edodes)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-09-15T12:45:44Z
dc.journal.volume
32
dc.journal.number
4
dc.journal.pagination
1-17
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Citores, Lucía. Universidad de Valladolid. Facultad de Ciencias; España
dc.description.fil
Fil: Ragucci, Sara. Seconda Universita Degli Studi Di Napoli; Italia
dc.description.fil
Fil: Russo, Rosita. Seconda Universita Degli Studi Di Napoli; Italia
dc.description.fil
Fil: Gay, Claudia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina
dc.description.fil
Fil: Chambery, Angela. Seconda Universita Degli Studi Di Napoli; Italia
dc.description.fil
Fil: Di Maro, Antimo. Seconda Universita Degli Studi Di Napoli; Italia
dc.description.fil
Fil: Iglesias, Rosario. Universidad de Valladolid; España
dc.description.fil
Fil: Ferreras, José M.. Universidad de Valladolid; España
dc.journal.title
Protein Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/pro.4621
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/pro.4621
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