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dc.contributor.author
Villalobos, Rafael
dc.contributor.author
Cordero, Salomón
dc.contributor.author
Vidales, Ana Maria
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dc.contributor.author
Domínguez, Armando
dc.date.available
2023-09-19T15:00:22Z
dc.date.issued
2006-07
dc.identifier.citation
Villalobos, Rafael; Cordero, Salomón; Vidales, Ana Maria; Domínguez, Armando; In silico study on the effects of matrix structure in controlled drug release; Elsevier Science; Physica A: Statistical Mechanics and its Applications; 367; 7-2006; 305-318
dc.identifier.issn
0378-4371
dc.identifier.uri
http://hdl.handle.net/11336/212070
dc.description.abstract
Purpose: To study the effects of drug concentration and spatial distribution of the medicament, in porous solid dosage forms, on the kinetics and total yield of drug release. Methods: Cubic networks are used as models of drug release systems. They were constructed by means of the dual site-bond model framework, which allows a substrate to have adequate geometrical and topological distribution of its pore elements. Drug particles can move inside the networks by following a random walk model with excluded volume interactions between the particles. The drug release time evolution for different drug concentration and different initial drug spatial distribution has been monitored. Results: The numerical results show that in all the studied cases, drug release presents an anomalous behavior, and the consequences of the matrix structural properties, i.e., drug spatial distribution and drug concentration, on the drug release profile have been quantified. Conclusions: The Weibull function provides a simple connection between the model parameters and the microstructure of the drug release device. A critical modeling of drug release from matrix-type delivery systems is important in order to understand the transport mechanisms that are implicated, and to predict the effect of the device design parameters on the release rate.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DRUG RELEASE
dc.subject
DUAL SITE-BOND MODEL
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INERT MATRIX
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MONTE CARLO SIMULATION
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WEIBULL EQUATION
dc.subject.classification
Otras Ciencias Físicas
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dc.subject.classification
Ciencias Físicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
In silico study on the effects of matrix structure in controlled drug release
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T20:33:45Z
dc.journal.volume
367
dc.journal.pagination
305-318
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Villalobos, Rafael. Universidad Autónoma Metropolitana; México
dc.description.fil
Fil: Cordero, Salomón. Universidad Autónoma Metropolitana; México
dc.description.fil
Fil: Vidales, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
dc.description.fil
Fil: Domínguez, Armando. Universidad Autónoma Metropolitana; México
dc.journal.title
Physica A: Statistical Mechanics and its Applications
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378437105011957
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.physa.2005.11.009
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