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dc.contributor.author
Lerut, Jan P.
dc.contributor.author
Gondolesi, Gabriel Eduardo
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dc.date.available
2023-09-19T13:39:01Z
dc.date.issued
2021-10
dc.identifier.citation
Lerut, Jan P.; Gondolesi, Gabriel Eduardo; Immunosuppression in liver and intestinal transplantation; Journal of Biological Chemistry; Best Practice & Research In Clinical Gastroenterology; 54-55; 101767; 10-2021; 1-17
dc.identifier.issn
1521-6918
dc.identifier.uri
http://hdl.handle.net/11336/212022
dc.description.abstract
Immunosuppression handling plays a key role in the early and long-term results of transplantation. The development of multiple immunosuppressive drugs led to numerous clincial trials searching to reach the ideal regimen. Due to heterogeneity of the studied patient cohorts and flaws in many, even randomized controlled, study designs, the answer still stands out. Nowadays triple-drug immunosuppression containing a calcineurin inhibitor (preferentially tacrolimus), an antimetabolite (using mycophenolate moffettil or Azathioprine) and short-term steroids with or without induction therapy (using anti-IL2 receptor blocker or anti-lymphocytic serum) is the preferred option in both liver and intestinal transplantation. This chapter aims, based on a critical review of the definitions of rejection, corticoresistant rejection and standard immunosuppression to give some reflections on how to reach an optimal immunosuppressive status and to conduct trials allowing to draw solid conclusions. Endpoints of future trials should not anymore focus on biopsy proven, acute and chronic, rejection but also on graft and patient survival. Correlation between early- and long-term biologic, immunologic and histopathologic findings will be fundamental to reach in much more patients the status of operational tolerance.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Journal of Biological Chemistry
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ACUTE REJECTION
dc.subject
CHRONC REJECTION
dc.subject
CLINICAL STUDIES
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CLINICAL TRIAL
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IMMUNOSUPPRESSION
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INTESTINAL TRANSPLANTATION
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LIVER BIOPSY
dc.subject
LIVER TRANSPLANTATION
dc.subject
TOLERANCE
dc.subject.classification
Trasplantes
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Immunosuppression in liver and intestinal transplantation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-09-18T13:28:31Z
dc.journal.volume
54-55
dc.journal.number
101767
dc.journal.pagination
1-17
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Lerut, Jan P.. Université Catholique de Louvain; Bélgica
dc.description.fil
Fil: Gondolesi, Gabriel Eduardo. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
dc.journal.title
Best Practice & Research In Clinical Gastroenterology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bpg.2021.101767
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1521691821000470
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