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Artículo

Acridones As Antiviral Agents: Synthesis, Chemical and Biological Properties

Sepúlveda, Claudia SoledadIcon ; Fascio, Mirta LilianaIcon ; García, C. C.; D'accorso, Norma BeatrizIcon ; Damonte, Elsa BeatrizIcon
Fecha de publicación: 04/2013
Editorial: Bentham Science Publishers
Revista: Current Medicinal Chemistry
ISSN: 0929-8673
e-ISSN: 1875-533X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Química Orgánica; Virología

Resumen

Acridones are a class of compounds that have attracted attention in recent years for their wide range of biological properties, including selective inhibition of diverse human pathogenic viruses. The wide spectrum of antiviral activity includes DNA and RNA viruses, such as herpes simplex virus, cytomegalovirus, adenovirus, hepatitis C virus, dengue virus, and Junin virus, among others, indicative of the involvement of cellular factors as potential targets of acridone derivatives. At the present, their precise mode of action is not clearly determined, although the predominant action seems to be centered on the synthesis of nucleic acids. Regarding this point, inhibitory activity against cellular and viral enzymes and the ability to intercalate into nucleic acid molecules was demonstrated for some acridone compounds. Then, the possibility of a multiple effect on different targets renewed interest in these agents for virus chemotherapy allowing a potent inhibitory effectiveness associated to less feasibility of generating antiviral resistance. This review summarizes the current knowledge regarding the methods of synthesis, the antiviral properties of acridone derivatives, their mechanism of action, and structural characteristics related to antiviral activity as well as the perspectives of this class of compounds for clinical application against human viral infections.
Palabras clave: Acridones , Antiviral Activity , Herpes Simplex Virus , Flavivirus , Arenavirus , Celular Target
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/2117
DOI: http://dx.doi.org/DOI:10.2174/0929867311320190002
URL: http://www.eurekaselect.com/109553/article
Colecciones
Articulos(CIHIDECAR)
Articulos de CENTRO DE INVESTIGACIONES EN HIDRATOS DE CARBONO
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Sepúlveda, Claudia Soledad; Fascio, Mirta Liliana; García, C. C.; D'accorso, Norma Beatriz; Damonte, Elsa Beatriz; Acridones As Antiviral Agents: Synthesis, Chemical and Biological Properties; Bentham Science Publishers; Current Medicinal Chemistry; 20; 19; 4-2013; 2402-2414
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