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dc.contributor.author
Fernandez, Ariel  
dc.date.available
2023-09-13T15:38:15Z  
dc.date.issued
2021-04  
dc.identifier.citation
Fernandez, Ariel; SARS-CoV-2 Glycosylation Suggests That Vaccines Should Have Adopted the S1 Subunit as Antigen; American Chemical Society; ACS Pharmacology and Translational Science; 4; 2; 4-2021; 1016-1017  
dc.identifier.issn
2575-9108  
dc.identifier.uri
http://hdl.handle.net/11336/211392  
dc.description.abstract
Extant SARS-CoV-2 vaccines use the trimeric spike (S) protein as antigen. In the virus, the spike region is extensively glycosylated, modulating immune surveillance. Because they have been defused, many epitopes in the vaccine sidetrack the immune response. Only the receptor binding domain within the S1 subunit is well-exposed to antibody recognition. After proteolytic virus activation, the S1 subunit offers additional epitopes with antibody exposure. Thus, vaccines adopting the S1 subunit as antigen would have been more efficacious than the existing ones.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Chemical Society  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
COVID-19 VACCINE  
dc.subject
EPITOPE  
dc.subject
PROTEIN GLYCOSYLATION  
dc.subject
PROTEOLYSIS  
dc.subject
SARS-COV-2  
dc.subject
STRUCTURAL BIOLOGY  
dc.subject
COVID-19  
dc.subject.classification
Otras Ciencias Químicas  
dc.subject.classification
Ciencias Químicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
SARS-CoV-2 Glycosylation Suggests That Vaccines Should Have Adopted the S1 Subunit as Antigen  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-09-13T12:01:03Z  
dc.journal.volume
4  
dc.journal.number
2  
dc.journal.pagination
1016-1017  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Fernandez, Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina  
dc.journal.title
ACS Pharmacology and Translational Science  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acsptsci.1c00036  

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