Mostrar el registro sencillo del ítem
dc.contributor.author
Marin Burgin, Antonia
dc.contributor.author
Kristan, William B.
dc.contributor.author
French, Kathleen A.
dc.date.available
2017-07-21T20:10:28Z
dc.date.issued
2008-05
dc.identifier.citation
Marin Burgin, Antonia; Kristan, William B.; French, Kathleen A.; From synapses to behavior: development of a sensory-motor circuit in the leech; John Wiley & Sons Inc; Developmental Neurobiology; 68; 6; 5-2008; 779-787
dc.identifier.issn
1932-8451
dc.identifier.uri
http://hdl.handle.net/11336/21126
dc.description.abstract
The development of neuronal circuits has been advanced greatly by the use of imaging techniques that reveal the activity of neurons during the period when they are constructing synapses and forming circuits. This review focuses on experiments performed in leech embryos to characterize the development of a neuronal circuit that produces a simple segmental behavior called "local bending." The experiments combined electrophysiology, anatomy, and FRET-based voltage-sensitive dyes (VSDs). The VSDs offered two major advantages in these experiments: they allowed us to record simultaneously the activity of many neurons, and unlike other imaging techniques, they revealed inhibition as well as excitation. The results indicated that connections within the circuit are formed in a predictable sequence: initially neurons in the circuit are connected by electrical synapses, forming a network that itself generates an embryonic behavior and prefigures the adult circuit; later chemical synapses, including inhibitory connections, appear, "sculpting" the circuit to generate a different, mature behavior. In this developmental process, some of the electrical connections are completely replaced by chemical synapses, others are maintained into adulthood, and still others persist and share their targets with chemical synaptic connections.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
From synapses to behavior: development of a sensory-motor circuit in the leech
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-18T14:50:44Z
dc.identifier.eissn
1932-846X
dc.journal.volume
68
dc.journal.number
6
dc.journal.pagination
779-787
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Marin Burgin, Antonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: Kristan, William B.. University of California at San Diego; Estados Unidos
dc.description.fil
Fil: French, Kathleen A.. University of California at San Diego; Estados Unidos
dc.journal.title
Developmental Neurobiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/dneu.20551
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/dneu.20551
Archivos asociados