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dc.contributor.author
Zhang, Ying
dc.contributor.author
Narajan, Sujatha
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Geiman, Eric
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Lanuza, Guillermo Marcos
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Velasquez, Tomoko
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Shanks, Bayle
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Akay, Turgay
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Dyck, Jason
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Pearson, Keir
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Gosgnach, Simon
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Fan, Chen-Ming
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Goulding, Martyn
dc.date.available
2017-07-21T19:48:17Z
dc.date.issued
2008-10
dc.identifier.citation
Zhang, Ying; Narajan, Sujatha; Geiman, Eric; Lanuza, Guillermo Marcos; Velasquez, Tomoko; et al.; V3 spinal neurons establish a robust and balanced locomotor rhythm during walking; Cell Press; Neuron; 60; 1; 10-2008; 84-96
dc.identifier.issn
0896-6273
dc.identifier.uri
http://hdl.handle.net/11336/21116
dc.description.abstract
A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3-mediated neurotransmission is selectively blocked by the expression of the tetanus toxin light chain subunit (TeNT), the regularity and robustness of the locomotor rhythm is severely perturbed. A similar degeneration in the locomotor rhythm occurs when the excitability of V3-derived neurons is reduced acutely by ligand-induced activation of the allatostatin receptor. The V3-derived neurons additionally function to balance the locomotor output between both halves of the spinal cord, thereby ensuring a symmetrical pattern of locomotor activity during walking. We propose that the V3 neurons establish a regular and balanced motor rhythm by distributing excitatory drive between both halves of the spinal cord.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Interneuron
dc.subject
Locomotion
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Cpg
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Spinal Cord
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
V3 spinal neurons establish a robust and balanced locomotor rhythm during walking
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-18T14:50:42Z
dc.identifier.eissn
1097-4199
dc.journal.volume
60
dc.journal.number
1
dc.journal.pagination
84-96
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Zhang, Ying. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil
Fil: Narajan, Sujatha. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil
Fil: Geiman, Eric. Salk Institute for Biological Studies; Estados Unidos
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Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil
Fil: Velasquez, Tomoko. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil
Fil: Shanks, Bayle. Salk Institute for Biological Studies; Estados Unidos
dc.description.fil
Fil: Akay, Turgay. University of Alberta; Canadá
dc.description.fil
Fil: Dyck, Jason. University of Alberta; Canadá
dc.description.fil
Fil: Pearson, Keir. University of Alberta; Canadá
dc.description.fil
Fil: Gosgnach, Simon. University of Alberta; Canadá
dc.description.fil
Fil: Fan, Chen-Ming. University Of Carnegie Mellon; Estados Unidos
dc.description.fil
Fil: Goulding, Martyn. Salk Institute for Biological Studies; Estados Unidos
dc.journal.title
Neuron
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0896627308008064
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.neuron.2008.09.027
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