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dc.contributor.author
Lifschitz, Adrian Luis
dc.contributor.author
Lloberas, Maria Mercedes
dc.contributor.author
Alvarez, Luis Ignacio
dc.contributor.author
Entrocasso, Carlos
dc.contributor.author
Ballent, Mariana
dc.contributor.author
Virkel, Guillermo Leon
dc.contributor.author
Luque, Sonia Elisabet
dc.contributor.author
Lanusse, Carlos Edmundo
dc.date.available
2023-09-08T13:12:51Z
dc.date.issued
2013
dc.identifier.citation
Moxidectin remains efficacious against ivermectin-resistant Haemonchus contortus: comparative pharmacological assessment of single and double dose-responses; 24º International Conference of the World Association for the Advancement of Veterinary Parasitology; Perth; Australia; 2013; 516-516
dc.identifier.uri
http://hdl.handle.net/11336/210905
dc.description.abstract
Although the macrocyclic lactones ivermectin (IVM) and moxidectin (MXD) share some pharmacological properties, a differential pattern of efficacy against resistant nematodes has been described (Vickers et al., 2001). Enhanced drug concentration within the worm and improved efficacy against resistant Haemonchus contortus have been recently reported after the intraruminal administration of IVM compared to the subcutaneous treatment (Lloberas et al., 2012). This work aimed to assess the relationship between anthelmintic activity and host tissue/parasite exposure for IVM and MXD in lambs naturally-infected with resistant H. contortus. The influence of a 2-fold dosage on the drug concentrations achieved at the host (bloodstream, gastrointestinal content/tissues) and within H. contortus were simultaneously evaluated with the clinical efficacy. Forty eight (48) naturally parasitised lambs were assigned into four (4) experimental groups and intraruminally treated with either IVM or MXD at 0.2 and 0.4 mg/kg. Blood samples were collected over 14 days post-treatment. Parasitological post-mortem examination was done at day 15 post-treatment. The recovered worms were identified by species and counted. Additionally, mucosal and fluid content samples and adult specimens of H. contortus were recovered at day 1 post-treatment. IVM and MXD were measured by HPLC. Both IVM and MXD concentration profiles measured within H. contortus reflected those observed in the abomasal contents. In spite of the high concentrations recovered from the abomasal content and within the worm, IVM completely failed to control H. contortus (0% efficacy) at both dose rates. Oppositely, MXD efficacy against this IVM-resistant H. contortus strain was 94.2 (therapeutic dosage) and 99.1% (double dose). The improved drug exposure (target worm) achieved after the oral/intraruminal treatment compared to the subcutaneous injection (Lloberas et al., 2012), as well, as the advantageous MXD efficacy performance observed at twice the dose should be seriously considered to optimise nematode control before a complete therapeutic failure is observed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
World Association for the Advancement of Veterinary Parasitology
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HAEMONCHUS CONTORTUS
dc.subject
RESISTENCIA
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IVERMECTIN
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MOXIDECTIN
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Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Moxidectin remains efficacious against ivermectin-resistant Haemonchus contortus: comparative pharmacological assessment of single and double dose-responses
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2023-05-18T14:08:26Z
dc.journal.pagination
516-516
dc.journal.pais
Australia
dc.journal.ciudad
Perth
dc.description.fil
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
dc.description.fil
Fil: Lloberas, Maria Mercedes. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Buenos Aires Sur. Estacion Experimental Agropecuaria Balcarce. Agencia de Extension Rural Tandil.; Argentina
dc.description.fil
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
dc.description.fil
Fil: Entrocasso, Carlos. Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Buenos Aires Sur. Estacion Experimental Agropecuaria Balcarce. Agencia de Extension Rural Tandil.; Argentina
dc.description.fil
Fil: Ballent, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
dc.description.fil
Fil: Virkel, Guillermo Leon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
dc.description.fil
Fil: Luque, Sonia Elisabet. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
dc.description.fil
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
dc.conicet.rol
Autor
dc.coverage
Internacional
dc.type.subtype
Conferencia
dc.description.nombreEvento
24º International Conference of the World Association for the Advancement of Veterinary Parasitology
dc.date.evento
2013-08-25
dc.description.ciudadEvento
Perth
dc.description.paisEvento
Australia
dc.type.publicacion
Book
dc.description.institucionOrganizadora
World Association for the Advancement of Veterinary Parasitology
dc.source.libro
Abstracts of the 24º International Conference of the World Association for the Advancement of Veterinary Parasitology
dc.date.eventoHasta
2013-08-29
dc.type
Conferencia
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