Shelterin genes, germ line mutations and chronic lymphocytic leukemia

Abstract

Telomeres are distinctive DNA-protein structures that cap the ends of linear chromosomes; they are essential to maintain chromosomal integrity and genome stability. Telomeres are composed by tandem repeats of the non-codificant DNA sequence TTAGGG bound by the shelterin complex. It contains six core proteins: TERF1, TERF2, POT1, ACD, TERF2IP and TINF2, which play fundamental roles in telomere protection, chromosomal stability and regulation of telomere length (TL) (1). In addition, the shelterin complex modulates telomerase activity at chromosome ends, recognizes telomeric DNA and remodels it into a t-loop, which protects the 3? overhang from being recognized as DNA damage. Alterations in the structure and function of any of these proteins may lead to undesirable DNA damage responses that could be associated to a role in tumorigenesis and cancer progression