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Artículo

Microbial RNA, the new PAMP of many faces

Milillo, María AyelénIcon ; Velásquez, Lis N.; Barrionuevo, PaulaIcon
Fecha de publicación: 06/2022
Editorial: Frontiers Media
Revista: Frontiers in Tropical Disease
ISSN: 2673-7515
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Traditionally, pathogen-associated molecular patterns (PAMPs) were described as structural molecular motifs shared by different classes of microorganisms. However, it was later discovered that the innate immune system is also capable of distinguishing metabolically active microbes through the detection of a special class of viability-associated PAMPs (vita-PAMPs). Indeed, recognition of vita-PAMPs triggers an extra warning sign not provoked by dead bacteria. Bacterial RNA is classified as a vita-PAMP since it stops being synthesized once the microbes are eliminated. Most of the studies in the literature have focused on the pro-inflammatory capacity of bacterial RNA on macrophages, neutrophils, endothelial cells, among others. However, we, and other authors, have shown that microbial RNA also has down-modulatory properties. More specifically, bacterial RNA can reduce the surface expression of MHC class I and MHC class II on monocytes/macrophages and help evade CD8+ and CD4+ T cell-mediated immune surveillance. This phenomenon has been described for several different bacteria and parasites, suggesting that microbial RNA plays a significant immunoregulatory role in the context of many infectious processes. Thus, beyond the pro-inflammatory capacity of microbial RNA, it seems to be a crucial component in the intricate collection of immune evasion strategies. This review focuses on the different facets of the immune modulating capacity of microbial RNA.
Palabras clave: VITA-PAMPS , MICROBIAL RNA SENSORS , RNA IMMUNOMODULATION , ADJUVANTS , IMMUNE EVASION
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/210657
DOI: http://dx.doi.org/10.3389/fitd.2022.924719
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Milillo, María Ayelén; Velásquez, Lis N. ; Barrionuevo, Paula; Microbial RNA, the new PAMP of many faces; Frontiers Media; Frontiers in Tropical Disease; 3; 6-2022; 1-9
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