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dc.contributor.author
Castillo Ruiz, Alexandra
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Cisternas, Carla Daniela
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Sturgeon, Hannah
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Forger, Nancy G.
dc.date.available
2023-09-06T12:34:20Z
dc.date.issued
2022-06
dc.identifier.citation
Castillo Ruiz, Alexandra; Cisternas, Carla Daniela; Sturgeon, Hannah; Forger, Nancy G.; Birth triggers an inflammatory response in the neonatal periphery and brain; Academic Press Inc Elsevier Science; Brain Behavior And Immunity; 104; 6-2022; 122-136
dc.identifier.issn
0889-1591
dc.identifier.uri
http://hdl.handle.net/11336/210653
dc.description.abstract
Birth is preceded by inflammation at the fetal/maternal interface. Additionally, the newborn experiences stimuli that under any other circumstance could elicit an immune response. It is unknown, however, whether birth elicits an inflammatory response in the newborn that extends to the brain. Moreover, it is unknown whether birth mode may alter such a response. To study these questions, we first measured corticosterone and pro- and anti-inflammatory cytokines in plasma of mouse offspring at several timepoints spaced closely before and after a vaginal or Cesarean birth. We found highest levels of IL-6 one day before birth and surges in corticosterone and IL-10 just after birth, regardless of birth mode. We next examined the neuroimmune response by measuring cytokine mRNA expression and microglial number and morphology in the paraventricular nucleus of the hypothalamus and hippocampus around the time of birth. We found a marked increase in TNF-α expression in both brain regions a day after birth, and rapid increases in microglial cell number in the first three days postnatal, with subtle differences by birth mode. To test whether the association between birth and cytokine production or expansion of microglia is causal, we manipulated birth timing. Remarkably, advancing birth by a day advanced the increases in all of the markers tested. Thus, birth triggers an immune response in the body and brain of offspring. Our results may provide a mechanism for effects of birth (e.g., acute changes in cell death and neural activation) previously reported in the newborn brain.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BIRTH MODE
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CA1 ORIENS
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CORTICOSTERONE
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CYTOKINES
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IBA1
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NEONATAL
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PARAVENTRICULAR NUCLEUS
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PRENATAL
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Birth triggers an inflammatory response in the neonatal periphery and brain
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-04T11:00:05Z
dc.journal.volume
104
dc.journal.pagination
122-136
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Castillo Ruiz, Alexandra. Georgia State University; Estados Unidos
dc.description.fil
Fil: Cisternas, Carla Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
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Fil: Sturgeon, Hannah. Georgia State University; Estados Unidos
dc.description.fil
Fil: Forger, Nancy G.. Georgia State University; Estados Unidos
dc.journal.title
Brain Behavior And Immunity
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0889159122001520?via%3Dihub
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbi.2022.05.021
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