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dc.contributor.author
Contó, Marcos Brandão
dc.contributor.author
Pautassi, Ricardo Marcos
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dc.contributor.author
Camarini, Rosana
dc.date.available
2023-09-06T12:34:00Z
dc.date.issued
2022-04
dc.identifier.citation
Contó, Marcos Brandão; Pautassi, Ricardo Marcos; Camarini, Rosana; Rewarding and antidepressant properties of ketamine and ethanol: effects on the BDNF and TrkB and p75NTR receptors; Pergamon-Elsevier Science Ltd; Neuroscience; 493; 4-2022; 1-14
dc.identifier.issn
0306-4522
dc.identifier.uri
http://hdl.handle.net/11336/210652
dc.description.abstract
There is a high level of comorbidity between depression and alcohol use disorder. Subanesthetic doses of ketamine induce short-acting and enduring antidepressant effects after a single or a few administrations. Considering such comorbidity, we assessed, in Swiss male mice, if ketamine-induced antidepressant-like effects would alter ethanol's rewarding effects; and, if ethanol pretreatment would alter the rewarding and antidepressant effects of ketamine. The role of the brain-derived neurotrophic factor (BDNF) and its high and low affinity receptors TrkB and p75NTR, respectively, in both reward and depression-related behaviors is well established. The present study assessed, in outbred Swiss male mice, the expression of these proteins in the prefrontal cortex and hippocampus. Ketamine did not alter the development of ethanol-induced conditioned place preference (CPP), yet ethanol inhibited the expression of CPP induced by 50 mg/kg ketamine. The antidepressant action of 50 mg/kg ketamine was attenuated after repeated treatment (i.e., developed tolerance), an effect blocked by ethanol preexposure; ethanol also inhibited the antidepressant effect of 30 mg/kg ketamine. Ketamine (50 mg/kg) and Ethanol–Ketamine (50 mg/kg) groups showed lower levels of 145 kDa TrkB in the hippocampus than Saline-treated group. Ethanol–Ketamine (50 mg/kg) decreased the hippocampal expression of p75NTR compared to Saline–Saline and Saline–Ethanol groups. Ketamine (50 mg/kg) induced hippocampal downregulation of 145 kDa TrkB may contribute to ketamine-induced antidepressant tolerance. Likewise, a relationship between low hippocampal levels of p75NTR in the Ethanol–Ketamine (50 mg/kg) and ketamine-induced CPP blockade may be considered. The findings underscore potential ethanol–ketamine interactions likely to undermine ketamine putative antidepressant effects.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CASPASE
dc.subject
CONDITIONED PLACE PREFERENCE
dc.subject
ETHANOL
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FORCED SWIMMING TEST
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KETAMINE
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NEUROTROPHIN
dc.subject.classification
Drogadicción
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Rewarding and antidepressant properties of ketamine and ethanol: effects on the BDNF and TrkB and p75NTR receptors
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-04T11:00:47Z
dc.journal.volume
493
dc.journal.pagination
1-14
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Contó, Marcos Brandão. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Camarini, Rosana. Universidade de Sao Paulo; Brasil
dc.journal.title
Neuroscience
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S030645222200197X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuroscience.2022.04.015
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