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dc.contributor.author
Contó, Marcos Brandão  
dc.contributor.author
Pautassi, Ricardo Marcos  
dc.contributor.author
Camarini, Rosana  
dc.date.available
2023-09-06T12:34:00Z  
dc.date.issued
2022-04  
dc.identifier.citation
Contó, Marcos Brandão; Pautassi, Ricardo Marcos; Camarini, Rosana; Rewarding and antidepressant properties of ketamine and ethanol: effects on the BDNF and TrkB and p75NTR receptors; Pergamon-Elsevier Science Ltd; Neuroscience; 493; 4-2022; 1-14  
dc.identifier.issn
0306-4522  
dc.identifier.uri
http://hdl.handle.net/11336/210652  
dc.description.abstract
There is a high level of comorbidity between depression and alcohol use disorder. Subanesthetic doses of ketamine induce short-acting and enduring antidepressant effects after a single or a few administrations. Considering such comorbidity, we assessed, in Swiss male mice, if ketamine-induced antidepressant-like effects would alter ethanol's rewarding effects; and, if ethanol pretreatment would alter the rewarding and antidepressant effects of ketamine. The role of the brain-derived neurotrophic factor (BDNF) and its high and low affinity receptors TrkB and p75NTR, respectively, in both reward and depression-related behaviors is well established. The present study assessed, in outbred Swiss male mice, the expression of these proteins in the prefrontal cortex and hippocampus. Ketamine did not alter the development of ethanol-induced conditioned place preference (CPP), yet ethanol inhibited the expression of CPP induced by 50 mg/kg ketamine. The antidepressant action of 50 mg/kg ketamine was attenuated after repeated treatment (i.e., developed tolerance), an effect blocked by ethanol preexposure; ethanol also inhibited the antidepressant effect of 30 mg/kg ketamine. Ketamine (50 mg/kg) and Ethanol–Ketamine (50 mg/kg) groups showed lower levels of 145 kDa TrkB in the hippocampus than Saline-treated group. Ethanol–Ketamine (50 mg/kg) decreased the hippocampal expression of p75NTR compared to Saline–Saline and Saline–Ethanol groups. Ketamine (50 mg/kg) induced hippocampal downregulation of 145 kDa TrkB may contribute to ketamine-induced antidepressant tolerance. Likewise, a relationship between low hippocampal levels of p75NTR in the Ethanol–Ketamine (50 mg/kg) and ketamine-induced CPP blockade may be considered. The findings underscore potential ethanol–ketamine interactions likely to undermine ketamine putative antidepressant effects.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CASPASE  
dc.subject
CONDITIONED PLACE PREFERENCE  
dc.subject
ETHANOL  
dc.subject
FORCED SWIMMING TEST  
dc.subject
KETAMINE  
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NEUROTROPHIN  
dc.subject.classification
Drogadicción  
dc.subject.classification
Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Rewarding and antidepressant properties of ketamine and ethanol: effects on the BDNF and TrkB and p75NTR receptors  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-07-04T11:00:47Z  
dc.journal.volume
493  
dc.journal.pagination
1-14  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Contó, Marcos Brandão. Universidade de Sao Paulo; Brasil  
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina  
dc.description.fil
Fil: Camarini, Rosana. Universidade de Sao Paulo; Brasil  
dc.journal.title
Neuroscience  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S030645222200197X  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuroscience.2022.04.015