Artículo
CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling
Dos Santos Claro, Paula Ayelen
; Silbermins, Micaela
; Inda, María Carolina
; Silberstein Cuña, Susana Iris
Fecha de publicación:
01/2023
Editorial:
Elsevier
Revista:
Progress in Molecular Biology and Translational Science
ISSN:
1877-1173
e-ISSN:
1878-0814
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Corticotropin releasing hormone (CRH) is crucial for basal and stress-initiated reactions in the hypothalamic-pituitary-adrenal axis (HPA) and extrahypothalamic brain circuits, where it acts as a neuromodulator to organize behavioral and humoral responses to stress. We review and describe cellular components and molecular mechanisms involved in CRH system signaling through G protein-coupled receptors (GPCRs) CRHR1 and CRHR2, under the current view of GPCR signaling from the plasma membrane but also from intracellular compartments, which establish the bases of signal resolution in space and time. Focus is placed on latest studies of CRHR1 signaling in physiologically significant contexts of the neurohormone function that disclosed new mechanistic features of cAMP production and ERK1/2 activation. We also introduce in a brief overview the pathophysiological function of the CRH system, underlining the need for a complete characterization of CRHRs signaling to design new and specific therapies for stress-related disorders.
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Articulos(IBIOBA - MPSP)
Articulos de INST. D/INV.EN BIOMED.DE BS AS-CONICET-INST. PARTNER SOCIEDAD MAX PLANCK
Articulos de INST. D/INV.EN BIOMED.DE BS AS-CONICET-INST. PARTNER SOCIEDAD MAX PLANCK
Citación
Dos Santos Claro, Paula Ayelen; Silbermins, Micaela; Inda, María Carolina; Silberstein Cuña, Susana Iris; CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling; Elsevier; Progress in Molecular Biology and Translational Science; 196; 1-2023; 229-260
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