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dc.contributor.author
Roisman, Alejandro  
dc.contributor.author
Slavutsky, Irma Rosa  
dc.date.available
2023-09-05T14:02:39Z  
dc.date.issued
2017-04  
dc.identifier.citation
Roisman, Alejandro; Slavutsky, Irma Rosa; MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis; University of Texas; Clinics in Oncology; 2; 1210; 4-2017; 1-3  
dc.identifier.issn
2474-1663  
dc.identifier.uri
http://hdl.handle.net/11336/210547  
dc.description.abstract
MicroRNAs (miRNAs) are short, endogenous singled-stranded noncoding RNAs whose dysregulation has been implicated in important biologic processes, including cancer development. The principal mechanism of action of these master regulators is to control gene expression by suppressing mRNA translation and reducing mRNA stability. In particular, the miR-17-92 cluster is the most frequently miRNA expressed in different subtypes of non-Hodgkin lymphomas. Its widespread dysregulation in these pathologies suggests this cluster as a new biomarker that may supplement lymphoma diagnosis and prognosis, and also as an attractive target to design novel strategies for cancer therapy.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
University of Texas  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
miRNAS  
dc.subject
LYMPHOID MALIGNANCIES  
dc.subject
PROGNOSTIC FACTORS  
dc.subject.classification
Genética Humana  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
MiR-17-92 cluster dysregulation in lymphoid malignancies: Its role in lymphomagenesis  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-09-05T12:10:34Z  
dc.journal.volume
2  
dc.journal.number
1210  
dc.journal.pagination
1-3  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Texas  
dc.description.fil
Fil: Roisman, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
dc.description.fil
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina  
dc.journal.title
Clinics in Oncology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.clinicsinoncology.com/open-access/mir-17-92-cluster-dysregulation-in-lymphoid-malignancies-its-role-in-limphomagenesis-1377.pdf  

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