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dc.contributor.author
Garcia Rill, Edgar
dc.contributor.author
D'Onofrio, Stasia
dc.contributor.author
Mahaffey, Susan
dc.contributor.author
Bisagno, Veronica
dc.contributor.author
Urbano Suarez, Francisco Jose
dc.date.available
2017-07-20T22:17:01Z
dc.date.issued
2015-06
dc.identifier.citation
Garcia Rill, Edgar; D'Onofrio, Stasia; Mahaffey, Susan; Bisagno, Veronica; Urbano Suarez, Francisco Jose; Pedunculopontine arousal system physiology - Implications for schizophrenia; Elsevier Science; Sleep Science; 8; 2; 6-2015; 82-91
dc.identifier.issn
1984-0063
dc.identifier.uri
http://hdl.handle.net/11336/21050
dc.description.abstract
Schizophrenia is characterized by major sleep/wake disturbances including increased vigilance and arousal, decreased slow wave sleep, and increased REM sleep drive. Other arousal-related symptoms include sensory gating deficits as exemplified by decreased habituation of the blink reflex. There is also dysregulation of gamma band activity, suggestive of disturbances in a host of arousal-related mechanisms. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of the disease. Recent discoveries on the physiology of the pedunculopontine nucleus help explain many of these disorders of arousal in, and point to novel therapeutic avenues for, schizophrenia.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Arousal
dc.subject
P50 Potential
dc.subject
Neuronal Calcium Sensor Protein
dc.subject
Calcium Channels
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Pedunculopontine arousal system physiology - Implications for schizophrenia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-11T13:25:53Z
dc.journal.volume
8
dc.journal.number
2
dc.journal.pagination
82-91
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Garcia Rill, Edgar. University Of Arkansas For Medical Sciences; Estados Unidos
dc.description.fil
Fil: D'Onofrio, Stasia. University Of Arkansas For Medical Sciences; Estados Unidos
dc.description.fil
Fil: Mahaffey, Susan. University Of Arkansas For Medical Sciences; Estados Unidos
dc.description.fil
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.journal.title
Sleep Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.slsci.2015.04.003
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1984006315000322
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