Mostrar el registro sencillo del ítem

dc.contributor.author
Garcia Rill, Edgar  
dc.contributor.author
D'Onofrio, Stasia  
dc.contributor.author
Mahaffey, Susan  
dc.contributor.author
Bisagno, Veronica  
dc.contributor.author
Urbano Suarez, Francisco Jose  
dc.date.available
2017-07-20T22:17:01Z  
dc.date.issued
2015-06  
dc.identifier.citation
Garcia Rill, Edgar; D'Onofrio, Stasia; Mahaffey, Susan; Bisagno, Veronica; Urbano Suarez, Francisco Jose; Pedunculopontine arousal system physiology - Implications for schizophrenia; Elsevier Science; Sleep Science; 8; 2; 6-2015; 82-91  
dc.identifier.issn
1984-0063  
dc.identifier.uri
http://hdl.handle.net/11336/21050  
dc.description.abstract
Schizophrenia is characterized by major sleep/wake disturbances including increased vigilance and arousal, decreased slow wave sleep, and increased REM sleep drive. Other arousal-related symptoms include sensory gating deficits as exemplified by decreased habituation of the blink reflex. There is also dysregulation of gamma band activity, suggestive of disturbances in a host of arousal-related mechanisms. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of the disease. Recent discoveries on the physiology of the pedunculopontine nucleus help explain many of these disorders of arousal in, and point to novel therapeutic avenues for, schizophrenia.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Arousal  
dc.subject
P50 Potential  
dc.subject
Neuronal Calcium Sensor Protein  
dc.subject
Calcium Channels  
dc.subject.classification
Neurociencias  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Pedunculopontine arousal system physiology - Implications for schizophrenia  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-07-11T13:25:53Z  
dc.journal.volume
8  
dc.journal.number
2  
dc.journal.pagination
82-91  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Garcia Rill, Edgar. University Of Arkansas For Medical Sciences; Estados Unidos  
dc.description.fil
Fil: D'Onofrio, Stasia. University Of Arkansas For Medical Sciences; Estados Unidos  
dc.description.fil
Fil: Mahaffey, Susan. University Of Arkansas For Medical Sciences; Estados Unidos  
dc.description.fil
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina  
dc.description.fil
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina  
dc.journal.title
Sleep Science  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.slsci.2015.04.003  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1984006315000322  

Archivos asociados
Thumbnail
 
Tamaño: 890.0Kb
Formato: PDF
.