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dc.contributor.author
Fernandez, Jennifer S.
dc.contributor.author
Tuttobene, Marisel Romina
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Montaña, Sabrina Daiana
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Subils, Tomás
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Cantera, Virginia
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Iriarte, Andres
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Tuchscherr, Lorena
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Ramirez, Maria Soledad
dc.date.available
2023-09-04T17:35:41Z
dc.date.issued
2022-04
dc.identifier.citation
Fernandez, Jennifer S. ; Tuttobene, Marisel Romina; Montaña, Sabrina Daiana; Subils, Tomás; Cantera, Virginia; et al.; Staphylococcus aureus α-Toxin Effect on Acinetobacter baumannii Behavior; MDPI; Biology; 11; 4; 4-2022; 1-13
dc.identifier.issn
2079-7737
dc.identifier.uri
http://hdl.handle.net/11336/210420
dc.description.abstract
Polymicrobial infections are more challenging to treat and are recognized as responsible for significant morbidity and mortality. It has been demonstrated that multiple Gram-negative organisms take advantage of the effects of Staphylococcus aureus α-toxin on mucosal host defense, resulting in proliferation and dissemination of the co-infecting pathogens. Through phenotypic approaches, we observed a decrease in the motility of A. baumannii A118 after exposure to cell-free conditioned media (CFCM) of S. aureus strains, USA300 and LS1. However, the motility of A. baumannii A118 was increased after exposure to the CFCM of S. aureus strains USA300 ∆hla and S. aureus LSI ∆agrA. Hemolytic activity was seen in A118, in the presence of CFCM of S. aureus LS1. Further, A. baumannii A118 showed an increase in biofilm formation and antibiotic resistance to tetracycline, in the presence of CFCM of S. aureus USA300. Transcriptomic analysis of A. baumannii A118, with the addition of CFCM from S. aureus USA300, was carried out to study A. baumannii response to S. aureus’ released molecules. The RNA-seq data analysis showed a total of 463 differentially expressed genes, associated with a wide variety of functions, such as biofilm formation, virulence, and antibiotic susceptibility, among others. The present results showed that A. baumannii can sense and respond to molecules secreted by S. aureus. These findings demonstrate that A. baumannii may perceive and respond to changes in its environment; specifically, when in the presence of CFCM from S. aureus.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ACINETOBACTER BAUMANNII
dc.subject
COMMENSALS
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POLYMICROBIAL INFECTIONS
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STAPHYLOCOCCUS AUREUS
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Staphylococcus aureus α-Toxin Effect on Acinetobacter baumannii Behavior
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T20:19:00Z
dc.journal.volume
11
dc.journal.number
4
dc.journal.pagination
1-13
dc.journal.pais
Suiza
dc.description.fil
Fil: Fernandez, Jennifer S.. California State University; Estados Unidos
dc.description.fil
Fil: Tuttobene, Marisel Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
dc.description.fil
Fil: Montaña, Sabrina Daiana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Subils, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Procesos Biotecnológicos y Químicos Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Procesos Biotecnológicos y Químicos Rosario; Argentina
dc.description.fil
Fil: Cantera, Virginia. Universidad de la Republica. Facultad de Medicina. Instituto de Higiene. Departamento de Desarrollo Biotecnológico.; Uruguay
dc.description.fil
Fil: Iriarte, Andres. Universidad de la Republica. Facultad de Medicina. Instituto de Higiene. Departamento de Desarrollo Biotecnológico.; Uruguay
dc.description.fil
Fil: Tuchscherr, Lorena. Jena University Hospital; Alemania
dc.description.fil
Fil: Ramirez, Maria Soledad. California State University; Estados Unidos
dc.journal.title
Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.3390/biology11040570
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