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dc.contributor.author
Au Yong, Sophie
dc.contributor.author
Firlak, Melike
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Draper, Emily R.
dc.contributor.author
Municoy, Sofia
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dc.contributor.author
Ashton, Mark D.
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Akien, Geoffrey R.
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Halcovitch, Nathan R.
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Baldock, Sara J.
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Martin Hirsch, Pierre
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Desimone, Martín Federico
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dc.contributor.author
Hardy, John G.
dc.date.available
2023-09-04T17:33:50Z
dc.date.issued
2022-11
dc.identifier.citation
Au Yong, Sophie; Firlak, Melike; Draper, Emily R.; Municoy, Sofia; Ashton, Mark D.; et al.; Electrochemically Enhanced Delivery of Pemetrexed from Electroactive Hydrogels; MDPI; Polymers; 14; 22; 11-2022; 1-19
dc.identifier.issn
2073-4360
dc.identifier.uri
http://hdl.handle.net/11336/210416
dc.description.abstract
Electroactive hydrogels based on derivatives of polyethyleneglycol (PEG), chitosan and polypyrrole were prepared via a combination of photopolymerization and oxidative chemical polymerization, and optionally doped with anions (e.g., lignin, drugs, etc.). The products were analyzed with a variety of techniques, including: FT-IR, UV-Vis, 1H NMR (solution state), 13C NMR (solid state), XRD, TGA, SEM, swelling ratios and rheology. The conductive gels swell ca. 8 times less than the non-conductive gels due to the presence of the interpenetrating network (IPN) of polypyrrole and lignin. A rheological study showed that the non-conductive gels are soft (G′ 0.35 kPa, G″ 0.02 kPa) with properties analogous to brain tissue, whereas the conductive gels are significantly stronger (G′ 30 kPa, G″ 19 kPa) analogous to breast tissue due to the presence of the IPN of polypyrrole and lignin. The potential of these biomaterials to be used for biomedical applications was validated in vitro by cell culture studies (assessing adhesion and proliferation of fibroblasts) and drug delivery studies (electrochemically loading the FDA-approved chemotherapeutic pemetrexed and measuring passive and stimulated release); indeed, the application of electrical stimulus enhanced the release of PEM from gels by ca. 10–15% relative to the passive release control experiment for each application of electrical stimulation over a short period analogous to the duration of stimulation applied for electrochemotherapy. It is foreseeable that such materials could be integrated in electrochemotherapeutic medical devices, e.g., electrode arrays or plates currently used in the clinic.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
BIOMEDICAL ENGINEERING
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DRUG DELIVERY
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HYDROGELS
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STIMULI-RESPONSIVE
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Bioproductos, Biomateriales, Bioplásticos, Biocombustibles, Bioderivados, etc.
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dc.subject.classification
Biotecnología Industrial
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Electrochemically Enhanced Delivery of Pemetrexed from Electroactive Hydrogels
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T22:55:22Z
dc.journal.volume
14
dc.journal.number
22
dc.journal.pagination
1-19
dc.journal.pais
Suiza
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dc.description.fil
Fil: Au Yong, Sophie. Lancaster University; Reino Unido
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Fil: Firlak, Melike. Lancaster University; Reino Unido
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Fil: Draper, Emily R.. University of Glasgow; Reino Unido
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Fil: Municoy, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
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Fil: Ashton, Mark D.. Lancaster University; Reino Unido
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Fil: Akien, Geoffrey R.. Lancaster University; Reino Unido
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Fil: Halcovitch, Nathan R.. Lancaster University; Reino Unido
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Fil: Baldock, Sara J.. Royal Preston Hospital; Reino Unido
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Fil: Martin Hirsch, Pierre. Lancaster University; Reino Unido
dc.description.fil
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil
Fil: Hardy, John G.. Lancaster University; Reino Unido
dc.journal.title
Polymers
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/polym14224953
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