Artículo
Larrea divaricata: antiinflammatory and antioxidant effects of on macrophages and low density lipoproteins
Peralta, Ignacio Nahuel
; Marrassini, Carla
; Saint Martin, Elina Malén
; Cogoi, Laura Carolina
; Alonso, María Rosario; Gugliucci, Alejandro; Anesini, Claudia Alejandra
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
03/2022
Editorial:
BioMed Central
Revista:
BMC Complementary Medicine and Therapies
ISSN:
2662-7671
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: The oxidized low density lipoprotein (ox-LDL) contributes to inflammation and oxidative stress through the activation of macrophages under hyperglycemia contributing to the development of diabetes mellitus and to atherosclerosis. Plants are a source of effective and innocuous antioxidants. Larrea divaricata Cav. (Zygophyllaceae) is used in Argentina folk medicine for its anti-inflammatory properties. Methods: The aim of this work was to study the antioxidant and anti-inflammatory effects of the aqueous extract (AE) of L. divaricata on macrophages under glucose stimulation and on human LDL and HDL particles under free radical generators. Results: AE reduced the lipid peroxidation (17%), nitric oxide (NO) (47-50%), tumor necrosis factor-α (TNF-α) (32%) and free radicals (50%) induced by glucose on macrophages. Also prevented HDL nitration (28%), thus preserving its function and structure and inhibited LDL oxidation. The effect on the nitrosative stress was mainly driven by nordihydroguaiaretic acid (NDGA). Conclusions: These results suggest a potential usefulness of AE as an adjuvant phytotherapy in patients with diabetes mellitus and atherosclerosis.
Palabras clave:
GLUCOSE
,
HDL
,
LARREA DIVARICATA
,
LDL
,
NDGA
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IQUIMEFA)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Citación
Peralta, Ignacio Nahuel; Marrassini, Carla; Saint Martin, Elina Malén; Cogoi, Laura Carolina; Alonso, María Rosario; et al.; Larrea divaricata: antiinflammatory and antioxidant effects of on macrophages and low density lipoproteins; BioMed Central; BMC Complementary Medicine and Therapies; 22; 1; 3-2022; 1-16
Compartir
Altmétricas