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dc.contributor.author
Parreño, Gladys Viviana
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Bai, Muqun
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Liu, Fangning
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Jing, Jiqiang
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Olney, Erika
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Li, Guohua
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Wen, Ke
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Yang, Xingdong
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Castellucc, Tammy Bui
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Kocher, Jacob F.
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Zhou, Xu
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Yuan, Lijuan
dc.date.available
2023-09-04T15:21:39Z
dc.date.issued
2022-09
dc.identifier.citation
Parreño, Gladys Viviana; Bai, Muqun; Liu, Fangning; Jing, Jiqiang; Olney, Erika; et al.; Probiotic as Adjuvant Significantly Improves Protection of the Lanzhou Trivalent Rotavirus Vaccine against Heterologous Challenge in a Gnotobiotic Pig Model of Human Rotavirus Infection and Disease; MDPI; Vaccines; 10; 9; 9-2022; 1-22
dc.identifier.issn
2076-393X
dc.identifier.uri
http://hdl.handle.net/11336/210364
dc.description.abstract
This preclinical study in the gnotobiotic (Gn) pig model of human rotavirus (HRV) infection and disease evaluates the effect of probiotic Lactobacillus rhamnosus GG (LGG) as a mucosal adjuvant on the immunogenicity and cross-protective efficacy of the Lanzhou live oral trivalent (G2, G3, G4) vaccine (TLV, aka LLR3). Gn pigs were immunized with three doses of TLV with or without concurrent administration of nine doses of LGG around the time of the first dose of the TLV vaccination, and were challenged orally with the virulent heterotypic Wa G1P[8] HRV. Three doses of TLV were highly immunogenic and conferred partial protection against the heterotypic HRV infection. LGG significantly enhanced the intestinal and systemic immune responses and improved the effectiveness of protection against the heterotypic HRV challenge-induced diarrhea and virus shedding. In conclusion, we demonstrated the immune-stimulating effects of probiotic LGG as a vaccine adjuvant and generated detailed knowledge regarding the cross-reactive and type-specific antibody and effector B and T cell immune responses induced by the TLV. Due to the low cost, ease of distribution and administration, and favorable safety profiles, LGG as an adjuvant has the potential to play a critical role in improving rotavirus vaccine efficacy and making the vaccines more cost-effective.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
GNOTOBIOTIC PIG
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LACTOBACILLUS RHAMNOSUS GG
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LANZHOU TRIVALENT VACCINE
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PROBIOTIC ADJUVANT
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ROTAVIRUS VACCINE
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Enfermedades Infecciosas
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Probiotic as Adjuvant Significantly Improves Protection of the Lanzhou Trivalent Rotavirus Vaccine against Heterologous Challenge in a Gnotobiotic Pig Model of Human Rotavirus Infection and Disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-08T00:35:01Z
dc.journal.volume
10
dc.journal.number
9
dc.journal.pagination
1-22
dc.journal.pais
Suiza
dc.journal.ciudad
Basel
dc.description.fil
Fil: Parreño, Gladys Viviana. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología e Innovaciones Tecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Virología e Innovaciones Tecnológicas; Argentina
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Fil: Bai, Muqun. Virginia-Maryland College of Veterinary Medicine; Estados Unidos
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Fil: Liu, Fangning. Virginia-Maryland College of Veterinary Medicine; Estados Unidos
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Fil: Jing, Jiqiang. Virginia-Maryland College of Veterinary Medicine; Estados Unidos
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Fil: Olney, Erika. Virginia-Maryland College of Veterinary Medicine; Estados Unidos
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Fil: Li, Guohua. Virginia-Maryland College of Veterinary Medicine; Estados Unidos
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Fil: Wen, Ke. Virginia-Maryland College of Veterinary Medicine; Estados Unidos
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Fil: Yang, Xingdong. Virginia-Maryland College of Veterinary Medicine; Estados Unidos
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Fil: Castellucc, Tammy Bui. Virginia-Maryland College of Veterinary Medicine; Estados Unidos
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Fil: Kocher, Jacob F.. Virginia-Maryland College of Veterinary Medicine; Estados Unidos
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Fil: Zhou, Xu. Lanzhou Institute of Biological Products; China
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Fil: Yuan, Lijuan. Virginia-Maryland College of Veterinary Medicine; Estados Unidos
dc.journal.title
Vaccines
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/vaccines10091529
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