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dc.contributor.author
da Costa, Valeria
dc.contributor.author
Mariño, Karina Valeria
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Rodríguez Zraquia, Santiago A.
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Festari, María Florencia
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Lores, Pablo
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Costa, Monique
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Landeira, Mercedes
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Rabinovich, Gabriel Adrián
dc.contributor.author
Vliet, Sandra J. van
dc.contributor.author
Freire, Teresa
dc.date.available
2023-09-01T01:15:46Z
dc.date.issued
2022-10
dc.identifier.citation
da Costa, Valeria; Mariño, Karina Valeria; Rodríguez Zraquia, Santiago A.; Festari, María Florencia; Lores, Pablo; et al.; Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 23; 19; 10-2022; 1-14
dc.identifier.issn
1422-0067
dc.identifier.uri
http://hdl.handle.net/11336/210110
dc.description.abstract
Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of N-acetyl-galactosamine (GalNAc) linked to a serine or threonine residue in proteins (α-GalNAc-O-Ser/Thr). The Tn antigen can be recognized by the Macrophage Galactose/GalNAc lectin (MGL), which mediates various immune regulatory and tolerogenic functions, mainly by reprogramming the maturation of function of dendritic cells (DCs). In this work, we generated two different Tn-expressing variants from the Lewis-type lung murine cancer cell line LL/2, which showed different alterations in the O-glycosylation pathways that influenced the interaction with mouse MGL2 and the immunomodulatory properties of DCs. Thus, the identification of the biological programs triggered by Tn+ cancer cells might contribute to an improved understanding of the molecular mechanisms elicited by MGL-dependent immune regulatory circuits.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Molecular Diversity Preservation International
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
LUNG CANCER
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MACROPHAGES
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TN ANTIGEN
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GLYCOSYLATION
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DENDRITIC CELLS
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TN ANTIGEN
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Patología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Lung tumor cells with different Tn antigen expression present distinctive immunomodulatory properties
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T18:17:30Z
dc.journal.volume
23
dc.journal.number
19
dc.journal.pagination
1-14
dc.journal.pais
Suiza
dc.journal.ciudad
Basel
dc.description.fil
Fil: da Costa, Valeria. Universidad de la República; Uruguay
dc.description.fil
Fil: Mariño, Karina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Rodríguez Zraquia, Santiago A.. Universidad de la República; Uruguay
dc.description.fil
Fil: Festari, María Florencia. Universidad de la República; Uruguay
dc.description.fil
Fil: Lores, Pablo. Universidad de la República; Uruguay
dc.description.fil
Fil: Costa, Monique. Universidad de la República; Uruguay
dc.description.fil
Fil: Landeira, Mercedes. Universidad de la República; Uruguay
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Vliet, Sandra J. van. Vrije Universiteit Amsterdam; Países Bajos
dc.description.fil
Fil: Freire, Teresa. Universidad de la República; Uruguay
dc.journal.title
International Journal of Molecular Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ijms231912047
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