Cumulus cells mitochondrial dysfunction in advanced-age women

Abstract

In the last decades, there has been a trend toward an increase in the number of women who delay childbearing to their late 30s and even to their 40s, in a search for economic, academic, and professional stability. In this context, ovarian aging and the concomitant diminished ovarian reserve (DOR) has become a highly relevant topic, because age-related ovarian dysfunction is a prevalent cause of infertility.