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dc.contributor.author
Rey, Rodolfo Alberto
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dc.date.available
2023-08-29T17:59:58Z
dc.date.issued
2022-01
dc.identifier.citation
Rey, Rodolfo Alberto; Recent advancement in the treatment of boys and adolescents with hypogonadism; SAGE Publications; Therapeutic Advances in Endocrinology and Metabolism; 13; 1-2022; 1-17
dc.identifier.issn
2042-0188
dc.identifier.uri
http://hdl.handle.net/11336/209810
dc.description.abstract
Clinical manifestations and the need for treatment varies according to age in males with hypogonadism. Early foetal-onset hypogonadism results in disorders of sex development (DSD) presenting with undervirilised genitalia whereas hypogonadism established later in foetal life presents with micropenis, cryptorchidism and/or micro-orchidism. After the period of neonatal activation of the gonadal axis has waned, the diagnosis of hypogonadism is challenging because androgen deficiency is not apparent until the age of puberty. Then, the differential diagnosis between constitutional delay of puberty and central hypogonadism may be difficult. During infancy and childhood, treatment is usually sought because of micropenis and/or cryptorchidism, whereas lack of pubertal development and relative short stature are the main complaints in teenagers. Testosterone therapy has been the standard, although off-label, in the vast majority of cases. However, more recently alternative therapies have been tested: aromatase inhibitors to induce the hypothalamic-pituitary-testicular axis in boys with constitutional delay of puberty and replacement with GnRH or gonadotrophins in those with central hypogonadism. Furthermore, follicle-stimulating hormone (FSH) priming prior to hCG or luteinizing hormone (LH) treatment seems effective to induce an enhanced testicular enlargement. Although the rationale for gonadotrophin or GnRH treatment is based on mimicking normal physiology, long-term results are still needed to assess their impact on adult fertility.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
SAGE Publications
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
ANORCHIA
dc.subject
CRYPTORCHIDISM
dc.subject
DELAY OF PUBERTY
dc.subject
DISORDERS OF SEX DEVELOPMENT
dc.subject
DSD
dc.subject
KALLMANN SYNDROME
dc.subject
KLINEFELTER SYNDROME
dc.subject
MICROPENIS
dc.subject.classification
Endocrinología y Metabolismo
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Recent advancement in the treatment of boys and adolescents with hypogonadism
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T23:05:20Z
dc.identifier.eissn
2042-0196
dc.journal.volume
13
dc.journal.pagination
1-17
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
dc.journal.title
Therapeutic Advances in Endocrinology and Metabolism
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/20420188211065660
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