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dc.contributor.author
Barttfeld, Pablo
dc.contributor.author
Uhrig, Lynn
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Sitt, Jacobo Diego
dc.contributor.author
Sigman, Mariano
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Jarraya, Béchir
dc.contributor.author
Dehaene, Stanislas
dc.date.available
2017-07-19T16:56:50Z
dc.date.issued
2015-01
dc.identifier.citation
Barttfeld, Pablo; Uhrig, Lynn; Sitt, Jacobo Diego; Sigman, Mariano; Jarraya, Béchir; et al.; Signature of consciousness in the dynamics of resting-state brain activity; National Academy Of Sciences; Proceedings Of The National Academy Of Sciences Of The United States Of America; 112; 3; 1-2015; 887-892
dc.identifier.issn
0027-8424
dc.identifier.uri
http://hdl.handle.net/11336/20936
dc.description.abstract
At rest, the brain is traversed by spontaneous functional connectivity patterns. Two hypotheses have been proposed for their origins: they may reflect a continuous stream of ongoing cognitive processes as well as random fluctuations shaped by a fixed anatomical connectivity matrix. Here we show that both sources contribute to the shaping of resting-state networks, yet with distinct contributions during consciousness and anesthesia. We measured dynamical functional connectivity with functional MRI during the resting state in awake and anesthetized monkeys. Under anesthesia, the more frequent functional connectivity patterns inherit the structure of anatomical connectivity, exhibit fewer small-world properties, and lack negative correlations. Conversely, wakefulness is characterized by the sequential exploration of a richer repertoire of functional configurations, often dissimilar to anatomical structure, and comprising positive and negative correlations among brain regions. These results reconcile theories of consciousness with observations of long-range correlation in the anesthetized brain and show that a rich functional dynamics might constitute a signature of consciousness, with potential clinical implications for the detection of awareness in anesthesia and brain-lesioned patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
National Academy Of Sciences
dc.relation
http://dx.doi.org/10.1073/pnas.1515029112
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Consciousness
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Anesthesia
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Brain States
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Signature of consciousness in the dynamics of resting-state brain activity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-12T18:05:47Z
dc.journal.volume
112
dc.journal.number
3
dc.journal.pagination
887-892
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington DC
dc.description.fil
Fil: Barttfeld, Pablo. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Uhrig, Lynn. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia
dc.description.fil
Fil: Sitt, Jacobo Diego. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Sigman, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad Torcuato Di Tella; Argentina
dc.description.fil
Fil: Jarraya, Béchir. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia
dc.description.fil
Fil: Dehaene, Stanislas. Commissariat A Energie Atomique; Francia. Institut National de la Santé et de la Recherche Médicale; Francia
dc.journal.title
Proceedings Of The National Academy Of Sciences Of The United States Of America
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1073/pnas.1418031112
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/112/3/887


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