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dc.contributor.author
Pusterla, Julio Martín
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dc.contributor.author
Cannas, Sergio Alejandro
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dc.contributor.author
Schneck, Emanuel
dc.contributor.author
Oliveira, Rafael Gustavo
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dc.date.available
2023-08-24T13:00:25Z
dc.date.issued
2022-05
dc.identifier.citation
Pusterla, Julio Martín; Cannas, Sergio Alejandro; Schneck, Emanuel; Oliveira, Rafael Gustavo; Purified myelin lipids display a critical mixing point at low surface pressure; Elsevier Science; Biochimica et Biophysica Acta - Biomembranes; 1864; 5; 5-2022; 1-9
dc.identifier.issn
0005-2736
dc.identifier.uri
http://hdl.handle.net/11336/209207
dc.description.abstract
Lipids extracted from Purified Myelin Membranes (LPMM) were spread as monomolecular films at the air/aqueous interface. The films were visualized by Brewster Angle Microscopy (BAM) at different lateral pressures (π) and ionic environments. Coexistence of Liquid-Expanded (LE) and cholesterol-enriched (CE) rounded domains persisted up to π ≈ 5 mN/m but the monolayers became homogeneous at higher surface pressures. Before mixing, the domains distorted to non-rounded domains. We experimentally measured the line tension (λ) for the lipid monolayers at the domain borders by a shape relaxation technique using non-homogeneous electric fields. Regardless of the subphase conditions, the obtained line tensions are of the order of pN and tended to decrease as lateral pressure increased toward the mixing point. From the mean square displacement of nested trapped domains, we also calculated the dipole density difference between phases (μ). A non-linear drop was detected in this parameter as the mixing point is approached. Here we quantitively evaluated the π-dependance of both parameters with proper power laws in the vicinity of the critical mixing surface pressure, and the exponents showed to be consistent with a critical phenomenon in the two-dimensional Ising universality class. This idea of bidimensionality was found to be compatible only for simplified lipidic systems, while for whole myelin monolayers, that means including proteins, no critical mixing point was detected. Finally, the line tension values were related with the thickness differences between phases (Δt) near the critical point.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CRITICAL MIXING POINT
dc.subject
DIPOLAR REPULSION
dc.subject
LANGMUIR MONOLAYERS
dc.subject
LINE TENSION
dc.subject
MEMBRANE DOMAINS
dc.subject
MYELIN LIPIDS
dc.subject.classification
Biofísica
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Purified myelin lipids display a critical mixing point at low surface pressure
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T21:32:04Z
dc.journal.volume
1864
dc.journal.number
5
dc.journal.pagination
1-9
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Pusterla, Julio Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. Universitat Technische Darmstadt; Alemania
dc.description.fil
Fil: Cannas, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
dc.description.fil
Fil: Schneck, Emanuel. Universitat Technische Darmstadt; Alemania
dc.description.fil
Fil: Oliveira, Rafael Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
dc.journal.title
Biochimica et Biophysica Acta - Biomembranes
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0005273622000165
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.bbamem.2022.183874
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