Artículo
Krüppel-like factor 6 participates in extravillous trophoblast cell differentiation and its expression is reduced in abnormally invasive placenta
Miranda, Andrea Lis
; Kourdova, Lucille Tihomirova
; Racca, Ana Cristina
; Cruz del Puerto, Mariano Matias Arzud
; Rojas, Maria Laura
; Marques, Aldilane L. X.; Silva, Elaine C. O.; Fonseca, Eduardo J. S.; Gazzoni, Yamila Natali
; Gruppi, Adriana
; Borbely, Alexandre U.; Genti de Raimondi, Susana
; Panzetta-Dutari, Graciela Maria del Valle
Fecha de publicación:
05/2022
Editorial:
Wiley
Revista:
FEBS Letters
ISSN:
0014-5793
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Trophoblast cell differentiation is of paramount importance for successful pregnancy. Krüppel-like factor 6 (KLF6), a transcription factor with diverse roles in cell physiology and tumor biology, is required for trophoblast differentiation through the syncytial pathway. Herein, we demonstrate that extravillous trophoblast (EVT) cell migration and mesenchymal phenotype are increased upon KLF6 downregulation or the expression of a deletion mutant lacking its transcriptional regulatory domain (KΔac). Raman spectroscopy revealed molecular modifications compatible with increased differentiation in cells stably expressing the KΔac mutant. Moreover, abnormally invasive placenta showed lower KLF6 immunostaining compared with the normal placenta. Thus, impaired KLF6 expression or function stimulates EVT migration and differentiation in vitro and may contribute to the physiopathology of the abnormally invasive placenta.
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Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Citación
Miranda, Andrea Lis; Kourdova, Lucille Tihomirova; Racca, Ana Cristina; Cruz del Puerto, Mariano Matias Arzud; Rojas, Maria Laura; et al.; Krüppel-like factor 6 participates in extravillous trophoblast cell differentiation and its expression is reduced in abnormally invasive placenta; Wiley; FEBS Letters; 596; 13; 5-2022; 1700-1719
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