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dc.contributor.author
Milan, Eduardo P.
dc.contributor.author
Bertolo, Mirella R. V.
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Martins, Virginia C. A.
dc.contributor.author
Sobrero, Cesar Enrique
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Plepis, Ana M. G.
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Fuhrmann Lieker, Thomas
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Horn, Marilia M.
dc.date.available
2023-08-23T15:56:47Z
dc.date.issued
2022-09
dc.identifier.citation
Milan, Eduardo P.; Bertolo, Mirella R. V.; Martins, Virginia C. A.; Sobrero, Cesar Enrique; Plepis, Ana M. G.; et al.; Effects of Mangosteen Peel Phenolic Compounds on Tilapia Skin Collagen-Based Mineralized Scaffold Properties; American Chemical Society; ACS Omega; 7; 38; 9-2022; 34022-34033
dc.identifier.issn
2470-1343
dc.identifier.uri
http://hdl.handle.net/11336/209100
dc.description.abstract
A proper valorization of biological waste sources for an effective conversion into composites for tissue engineering is discussed in this study. Hence, the collagen and the phenolic compound applied in this investigation were extracted from waste sources, respectively, fish industry rejects and the peels of the mangosteen fruit. Porous scaffolds were prepared by combining both components at different compositions and mineralized at different temperatures to evaluate the modifications in the biomimetic formation of apatite. The inclusion of mangosteen extract showed the advantage of increasing the collagen denaturation temperature, improving the stability of its triple helix. Moreover, the extract provided antioxidant activity due to its phenolic composition, as confirmed by 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant assays. Mineralization was successfully achieved as indicated by thermogravimetry and scanning electron microscopy. A higher temperature and a lower extract concentration reduced the calcium phosphate deposits. The extract also affected the pore size, particularly at a lower concentration. The X-ray diffraction pattern identified a low degree of crystallization. A high mineralization temperature induced the formation of smaller crystallites ranging from 18.9 to 25.4 nm. Although the deposited hydroxyapatite showed low crystallinity, the scaffolds are suitable for bone tissue applications and may be effective in controlling the resorbability rate in tissue regeneration.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
X-Ray
dc.subject.classification
Ingeniería de los Materiales
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dc.subject.classification
Ingeniería de los Materiales
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Effects of Mangosteen Peel Phenolic Compounds on Tilapia Skin Collagen-Based Mineralized Scaffold Properties
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-17T17:51:45Z
dc.journal.volume
7
dc.journal.number
38
dc.journal.pagination
34022-34033
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Milan, Eduardo P.. Universidade de Sao Paulo; Brasil
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Fil: Bertolo, Mirella R. V.. Universidade de Sao Paulo; Brasil
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Fil: Martins, Virginia C. A.. Universidade de Sao Paulo; Brasil
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Fil: Sobrero, Cesar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; Argentina
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Fil: Plepis, Ana M. G.. Universidade de Sao Paulo; Brasil
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Fil: Fuhrmann Lieker, Thomas. University of Kassel; Alemania
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Fil: Horn, Marilia M.. University of Kassel; Alemania
dc.journal.title
ACS Omega
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acsomega.2c03266
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