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dc.contributor.author
Souza, Iara da C.
dc.contributor.author
Morozesk, Mariana
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Siqueira, Priscila
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Zini, Enzo
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Galter, Iasmini N.
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Moraes, Daniel A. de
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Matsumoto, Silvia T.
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Wunderlin, Daniel Alberto
dc.contributor.author
Elliott, Michael
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Fernandes, Marisa N.
dc.date.available
2023-08-22T17:18:13Z
dc.date.issued
2022-03-25
dc.identifier.citation
Souza, Iara da C.; Morozesk, Mariana; Siqueira, Priscila; Zini, Enzo; Galter, Iasmini N.; et al.; Metallic nanoparticle contamination from environmental atmospheric particulate matter in the last slab of the trophic chain: Nanocrystallography, subcellular localization and toxicity effects; Elsevier; Science of the Total Environment; 814; 25-3-2022; 1-12
dc.identifier.issn
0048-9697
dc.identifier.uri
http://hdl.handle.net/11336/208928
dc.description.abstract
Atmospheric particulate material (PM) from mining and steel industries comprises several metallic contaminants. PM10 samples collected in a Brazilian region with a recognized influence of the steel and iron pelletizing industries were used to investigate metallic nanoparticle incorporation into human fibroblast cells (MRC-5). MRC-5 cells were exposed to 0 (control, ultrapure water), 2.5, 5, 10, 20 and 40 μg PM10 mL−1, for 24 h. Cytotoxic and genotoxic dose-response effects were observed on lysosome and DNA structure, and concentrations high as 20 and 40 μg PM10 mL−1 induced elevated cell death. Ultrastructure analyses showed aluminosilicate, iron, and the emerging metallic contaminants titanium, bismuth, and cerium nanoparticles were incorporated into lung cells, in which the nanocrystallography analysis indicated the bismuth as Bi2O3. All internalized metallic nanoparticles were free and unbound in the cytoplasm and nucleus thereby indicating bioavailability and potential interaction to biological processes and cellular structures. Pearson's correlation analysis showed Fe, Ni, Al, Cr, Pb and Hg as the main cytotoxic elements which are associated with the stainless steel production. The presence of internalized nanoparticles in human lung cells exposed to environmental atmospheric matter highlights the need for a greater effort by regulatory agencies to understand their potential damage and hence the need for future regulation, especially of emerging metallic contaminants.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BISMUTH
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CERIUM
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COMET ASSAY
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NANOCRYSTALLOGRAPHY
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NANOPARTICLES
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TITANIUM
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Metallic nanoparticle contamination from environmental atmospheric particulate matter in the last slab of the trophic chain: Nanocrystallography, subcellular localization and toxicity effects
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T19:14:17Z
dc.identifier.eissn
1879-1026
dc.journal.volume
814
dc.journal.pagination
1-12
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Souza, Iara da C.. Universidade Federal do São Carlos; Brasil
dc.description.fil
Fil: Morozesk, Mariana. Universidade Federal do São Carlos; Brasil
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Fil: Siqueira, Priscila. Universidade Federal do São Carlos; Brasil
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Fil: Zini, Enzo. Universidade Federal do Espírito Santo; Brasil
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Fil: Galter, Iasmini N.. Universidade Federal do Espírito Santo; Brasil
dc.description.fil
Fil: Moraes, Daniel A. de. Universidade de Sao Paulo; Brasil
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Fil: Matsumoto, Silvia T.. Universidade Federal do Espírito Santo; Brasil
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Fil: Wunderlin, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina
dc.description.fil
Fil: Elliott, Michael. University of Hull. Departament of Biological Sciences; Reino Unido
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Fil: Fernandes, Marisa N.. Universidade Federal do São Carlos; Brasil
dc.journal.title
Science of the Total Environment
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0048969721077639
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.scitotenv.2021.152685
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