Artículo
A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene?
Toro, Ayelen Rayen
; Ruiz, María Sol
; Lage Vickers, Sofia
; Sanchis, Pablo Antonio
; Sabater, Agustina Ayelen
; Pascual, Gastón Mario
; Seniuk, Rocio Alejandra
; Cascardo, Florencia Laura
; Ledesma Bazan, Paula Sabrina
; Vilicich, Felipe; Vazquez, Elba Susana
; Gueron, Geraldine
Fecha de publicación:
01/2022
Editorial:
MDPI
Revista:
Antioxidants
ISSN:
2076-3921
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Heme oxygenase 1 (HO-1), the rate-limiting enzyme in heme degradation, is involved in the maintenance of cellular homeostasis, exerting a cytoprotective role by its antioxidative and anti-inflammatory functions. HO-1 and its end products, biliverdin, carbon monoxide and free iron (Fe2+), confer cytoprotection against inflammatory and oxidative injury. Additionally, HO-1 exerts antiviral properties against a diverse range of viral infections by interfering with replication or activating the interferon (IFN) pathway. Severe cases of coronavirus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are characterized by systemic hyperinflammation, which, in some cases, leads to severe or fatal symptoms as a consequence of respiratory failure, lung and heart damage, kidney failure, and nervous system complications. This review summarizes the current research on the protective role of HO-1 in inflammatory diseases and against a wide range of viral infections, positioning HO-1 as an attractive target to ameliorate clinical manifestations during COVID-19.
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Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Toro, Ayelen Rayen; Ruiz, María Sol; Lage Vickers, Sofia; Sanchis, Pablo Antonio; Sabater, Agustina Ayelen; et al.; A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene?; MDPI; Antioxidants; 11; 2; 1-2022; 1-22
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