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dc.contributor.author
Ruiz Jimenez, Caleb
dc.contributor.author
Celias, Daiana Pamela
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Valdés, Bianca
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Ramos Pérez, Willy D.
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Cervi, Laura Alejandra
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Espino, Ana M.
dc.date.available
2023-08-22T15:08:33Z
dc.date.issued
2021-12
dc.identifier.citation
Ruiz Jimenez, Caleb; Celias, Daiana Pamela; Valdés, Bianca; Ramos Pérez, Willy D.; Cervi, Laura Alejandra; et al.; Fasciola hepatica fatty acid binding protein (Fh12) induces apoptosis and tolerogenic properties in murine bone marrow derived dendritic cells; Academic Press Inc Elsevier Science; Experimental Parasitology; 231; 12-2021; 1-20
dc.identifier.issn
0014-4894
dc.identifier.uri
http://hdl.handle.net/11336/208875
dc.description.abstract
In a previous study we demonstrated that Fasciola hepatica fatty acid binding protein (Fh12) significantly suppress macrophage function by inhibiting IL-6, IL-1β, tumor necrosis factor (TNF)-α and IL-12 production in TLR4-stimulated murine macrophages, an effect mediated through the signaling of CD14 co-receptor without affecting the viability of these cells. Given that dendritic cells (DCs) are immune cells that play a central role in the initiation of primary immune responses and that are the only antigen-presenting cells capable of stimulating naïve T-cells, in the present study we investigated the effect of Fh12 on DCs. We found that Fh12 exerts a strong suppressive effect on activation and function of DCs. However, in contrast to the effect observed on macrophages, Fh12 induces early and late apoptosis of DCs being this phenomenon dose-dependent and CD14-coreceptor independent. At low concentration Fh12 modulates the LPS-induced DCs maturation status by suppressing the MHC-II, and co-stimulatory molecules CD40 and CD80 surface expression together with the pro-inflammatory cytokines IL-12p70 and IL-6 production whereas increase the IL-10 levels. Besides, Fh12 decreased the ability of LPS-activated DCs to induce IFN-γ production against allogeneic splenocytes, while increasing IL-4 production. We have described for the first time the ability of Fh12 to modify selectively the viability of DCs by apoptosis induction. The selective diminution in DCs survival could be a F. hepatica strategy in order to prevent a host immune response during the earliest phases of infection.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
APOPTOSIS
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DENDRITIC CELLS
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FASCIOLA HEPATICA
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FATTY ACID BINDING PROTEIN
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Fasciola hepatica fatty acid binding protein (Fh12) induces apoptosis and tolerogenic properties in murine bone marrow derived dendritic cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-08-16T11:12:09Z
dc.journal.volume
231
dc.journal.pagination
1-20
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Ruiz Jimenez, Caleb. Universidad de Puerto Rico; Puerto Rico
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Fil: Celias, Daiana Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Valdés, Bianca. Universidad de Puerto Rico; Puerto Rico
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Fil: Ramos Pérez, Willy D.. Universidad de Puerto Rico; Puerto Rico
dc.description.fil
Fil: Cervi, Laura Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Espino, Ana M.. Universidad de Puerto Rico; Puerto Rico
dc.journal.title
Experimental Parasitology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/https://doi.org/10.1016/j.exppara.2021.108174
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/34752732/
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