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Artículo

IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment

Felcher, Carla MaríaIcon ; Bogni, Emilia SoledadIcon ; Kordon, Edith ClaudiaIcon
Fecha de publicación: 02/2022
Editorial: MDPI
Revista: International Journal of Molecular Sciences
ISSN: 1422-0067
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

The IL-6 cytokine family is a group of signaling molecules with wide expression and function across vertebrates. Each member of the family signals by binding to its specific receptor and at least one molecule of gp130, which is the common transmembrane receptor subunit for the whole group. Signal transduction upon stimulation of the receptor complex results in the activation of multiple downstream cascades, among which, in mammary cells, the JAK-STAT3 pathway plays a central role. In this review, we summarize the role of the IL-6 cytokine family—specifically IL-6 itself, LIF, OSM, and IL-11—as relevant players during breast cancer progression. We have compiled evidence indicating that this group of soluble factors may be used for early and more precise breast cancer diagnosis and to design targeted therapy to treat or even prevent metastasis development, particularly to the bone. Expression profiles and possible therapeutic use of their specific receptors in the different breast cancer subtypes are also described. In addition, participation of these cytokines in pathologies of the breast linked to lactation and involution of the gland, as post-partum breast cancer and mastitis, is discussed.
Palabras clave: BREAST CANCER , IL-11 , IL-6 , LIF , MASTITIS , OSM , TUMOR MICROENVIRONMENT
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/208866
URL: https://www.mdpi.com/1422-0067/23/3/1809
DOI: http://dx.doi.org/10.3390/ijms23031809
Colecciones
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Citación
Felcher, Carla María; Bogni, Emilia Soledad; Kordon, Edith Claudia; IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment; MDPI; International Journal of Molecular Sciences; 23; 3; 2-2022; 1-15
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