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dc.contributor.author
Corrêa Fontana, Letícia  
dc.contributor.author
Guerra Pinto, Juliana  
dc.contributor.author
Vitorio, Gabrielle dos Santos  
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Ferreira, Isabelle  
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Pacheco Soares, Cristina  
dc.contributor.author
Mamone, Leandro Ariel  
dc.contributor.author
Ferreira Strixino, Juliana  
dc.date.available
2023-08-18T18:52:20Z  
dc.date.issued
2022-03  
dc.identifier.citation
Corrêa Fontana, Letícia; Guerra Pinto, Juliana; Vitorio, Gabrielle dos Santos; Ferreira, Isabelle; Pacheco Soares, Cristina; et al.; Photodynamic effect of protoporphyrin IX in gliosarcoma 9l/lacZ cell line; Elsevier Science; Photodiagnosis Photodynamic Therapy; 37; 3-2022; 1-11  
dc.identifier.issn
1572-1000  
dc.identifier.uri
http://hdl.handle.net/11336/208784  
dc.description.abstract
Photodynamic Therapy (PDT) is an oncologic treatment, producing reactive oxygen species (ROS) to induce the death of cancer cells. This study aimed to evaluate the action of PDT on gliosarcoma cells, using protoporphyrin IX as PS by incubation with the precursor aminolevulinic acid (ALA). An LED device was used with a light dose of 10 J/cm². The success of the therapy proved to be dependent on the concentration of ALA, and an incubation time of 4 h required for an effective response. Cell death was prevalent due to necrosis when assessed 18 h post-PDT. ALA proved to be an option to PDT in cells of the 9 L/lacZ, with the protocol tested.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
5-ALA  
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AMINOLEVULINIC ACID  
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BRAIN CANCER  
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GLIOSARCOMA  
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PHOTODYNAMIC THERAPY  
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Otras Medicina Básica  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Photodynamic effect of protoporphyrin IX in gliosarcoma 9l/lacZ cell line  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-07-10T11:07:40Z  
dc.journal.volume
37  
dc.journal.pagination
1-11  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Corrêa Fontana, Letícia. Universidade Do Vale Do Paraiba; Brasil  
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Fil: Guerra Pinto, Juliana. Universidade Do Vale Do Paraiba; Brasil  
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Fil: Vitorio, Gabrielle dos Santos. Universidade Do Vale Do Paraiba; Brasil  
dc.description.fil
Fil: Ferreira, Isabelle. Universidade Do Vale Do Paraiba; Brasil  
dc.description.fil
Fil: Pacheco Soares, Cristina. Universidade Do Vale Do Paraiba; Brasil  
dc.description.fil
Fil: Mamone, Leandro Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; Argentina  
dc.description.fil
Fil: Ferreira Strixino, Juliana. Universidade Do Vale Do Paraiba; Brasil  
dc.journal.title
Photodiagnosis Photodynamic Therapy  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1572100021004865  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.pdpdt.2021.102669  

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