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dc.contributor.author
Russell, Ashley E.
dc.contributor.author
Liao, Zhaohao
dc.contributor.author
Tkach, Mercedes
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dc.contributor.author
Tarwater, Patrick M.
dc.contributor.author
Ostrowski, Matias
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dc.contributor.author
Théry, Clotilde
dc.contributor.author
Witwer, Kenneth W.
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dc.date.available
2023-08-18T18:39:22Z
dc.date.issued
2022-05
dc.identifier.citation
Russell, Ashley E.; Liao, Zhaohao; Tkach, Mercedes; Tarwater, Patrick M.; Ostrowski, Matias; et al.; Cigarette smoke-induced extracellular vesicles from dendritic cells alter T-cell activation and HIV replication; Elsevier Ireland; Toxicology Letters; 360; 5-2022; 33-43
dc.identifier.issn
0378-4274
dc.identifier.uri
http://hdl.handle.net/11336/208779
dc.description.abstract
Despite decreased rates of tobacco smoking in many areas, cigarette smoking remains a major contributor to many health problems. Cigarette smoking can reduce immune system functioning while concurrently increasing inflammation. Dendritic cells in the lung exposed to cigarette smoke become stimulated and go on to activate T-cells. Extracellular vesicles (EVs) are nano-sized particles released by cells. They participate in intercellular communication by transferring functional proteins and nucleic acids to recipient cells and have been implicated in immune responses. For example, they can display MHC-peptide complexes to activate T-cells. In the current study, we sought to understand the role of cigarette smoke extract (CSE) on dendritic cell-derived EVs and their capacity to activate and differentiate T-cells. Primary human dendritic cells (iDCs) were exposed to CSE and EVs were separated and characterized. We exposed autologous primary CD4 + T-cells to iDC-EVs and observed T helper cell populations skewing towards Th1 and Th17 phenotypes. As HIV + individuals are disproportionately likely to be current smokers, we also examined the effects of iDC-EVs on acutely infected T-cells as well as on a cell model of HIV latency (ACH-2). We found that in most cases, iDC-CSE EVs tended to reduce p24 release from the acutely infected primary T-cells, albeit with great variability. We did not observe large effects of iDC-EVs or direct CSE exposure on p24 release from the ACH-2 cell line. Together, these data suggest that iDC-CSE EVs have the capacity to modulate the immune responses, in part by pushing T-cells towards Th1 and Th17 phenotypes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CIGARETTE SMOKE
dc.subject
DENDRITIC CELLS
dc.subject
EXTRACELLULAR VESICLES
dc.subject
HIV
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IMMUNE SYSTEM
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T-CELLS
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Cigarette smoke-induced extracellular vesicles from dendritic cells alter T-cell activation and HIV replication
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-06T22:42:14Z
dc.journal.volume
360
dc.journal.pagination
33-43
dc.journal.pais
Irlanda
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dc.description.fil
Fil: Russell, Ashley E.. The Behrend College; Estados Unidos. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Liao, Zhaohao. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Tkach, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Institute Curie; Francia
dc.description.fil
Fil: Tarwater, Patrick M.. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
dc.description.fil
Fil: Théry, Clotilde. Institute Curie; Francia
dc.description.fil
Fil: Witwer, Kenneth W.. University Johns Hopkins; Estados Unidos
dc.journal.title
Toxicology Letters
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378427422000509
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.toxlet.2022.02.004
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