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Artículo

Opportunities, obstacles and current challenges of flavonoids for luminal and triple-negative breast cancer therapy

Vachetta, Vanina SolIcon ; Marder, Nora MarielIcon ; Troncoso, María FernandaIcon ; Elola, Maria TeresaIcon
Fecha de publicación: 12/2022
Editorial: Elsevier
Revista: European Journal of Medicinal Chemistry Reports
ISSN: 2772-4174
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otros Tópicos Biológicos

Resumen

Flavonoids are a large group of polyphenols with numerous biological effects on cancer cells. They have been shown to affect proliferation via cell cycle arrest, apoptosis and necrosis and to exert anti-oxidant, anti-inflammatory and anti-mutagenic actions. Anti-cancer effects of flavonoids, mostly in preclinical evaluations, should be translated into clinical cancer treatment research, where evidence is still scarce. Although therapies targeting primary breast tumors have markedly improved, those targeting elusive micro-metastases are less effective. In this scenario, the present review discusses the anti-tumor effects of different simple natural and synthetic flavonoids on luminal and triple-negative breast cancer, highlighting biological effects such as apoptosis, epithelial-mesenchymal transition reversion, cell migration and invasion inhibition, metalloprotease inactivation/down-regulation and anti-angiogenesis, as well as compiling in vivo treatments in experimental tumor models and some specific clinical trials. In addition, this review discusses the mechanisms underlying flavonoid anti-tumor effects. Moreover, although flavonoids may be regarded as a spectrum of promising polyphenols with multifaceted anti-tumor effects, mainly applicable to metastatic breast cancer management, some major challenges and concerns about potential flavonoid therapy in luminal and triple-negative breast cancer are also discussed.
Palabras clave: ANTI-ANGIOGENESIS , ANTI-INVASION , APOPTOSIS , FLAVONOIDS , LUMINAL BREAST CANCER , TRIPLE-NEGATIVE
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/208725
URL: https://linkinghub.elsevier.com/retrieve/pii/S2772417422000498
DOI: http://dx.doi.org/10.1016/j.ejmcr.2022.100077
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Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Citación
Vachetta, Vanina Sol; Marder, Nora Mariel; Troncoso, María Fernanda; Elola, Maria Teresa; Opportunities, obstacles and current challenges of flavonoids for luminal and triple-negative breast cancer therapy; Elsevier; European Journal of Medicinal Chemistry Reports; 6; 12-2022; 1-26
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