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dc.contributor.author
Palermo, Ana María  
dc.contributor.author
Mudry, Marta Dolores  
dc.date.available
2017-07-18T21:01:50Z  
dc.date.issued
2013-07  
dc.identifier.citation
Palermo, Ana María; Mudry, Marta Dolores; Metronidazole Induced DNA Damage in Somatic Cells of Drosophila melanogaster; Bentham Science Publishers; Current Drug Safety; 8; 3; 7-2013; 195-198  
dc.identifier.issn
1574-8863  
dc.identifier.uri
http://hdl.handle.net/11336/20871  
dc.description.abstract
The standard version of the wing somatic mutation and recombination test (SMART) in Drosophila melanogaster was employed in order to evaluate the genotoxic potential of metronidazole (MTZ) as a function of exposure concentration. MTZ was administered by chronic feeding of 3-day-old larvae with the parenteral solution at 0, 500, 1000 and 2000 μg/ml until pupation. The marker-heterozygous progeny (mwh+/+flr3) with phenotypically wild-type wings was analyzed. Non significant differences were found between control and each MTZ concentration tested for single small spots (SSS) frequencies. Large single spots (LSS) and twin spots (TS) were significantly increased with the higher dose. MTZ treatments with 1000 and 2000 μg/ml also significantly increased the frequency of Total spots. These findings suggest that MTZ is genotoxic in the present experimental conditions and induces recombinagenesis and/or gene conversion, two major mechanisms that cause loss of heterocigosity and could play an important role in tumorigenesis and carcinogenesis processes.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Bentham Science Publishers  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Drosophila  
dc.subject
Genotoxicity  
dc.subject
Metronidazole (Mtz)  
dc.subject
Wing Spot Assay  
dc.subject.classification
Otros Tópicos Biológicos  
dc.subject.classification
Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Metronidazole Induced DNA Damage in Somatic Cells of Drosophila melanogaster  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-07-18T15:34:04Z  
dc.identifier.eissn
2212-3911  
dc.journal.volume
8  
dc.journal.number
3  
dc.journal.pagination
195-198  
dc.journal.pais
Emiratos Árabes Unidos  
dc.journal.ciudad
Sharjah  
dc.description.fil
Fil: Palermo, Ana María. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas Para la Defensa; Argentina  
dc.description.fil
Fil: Mudry, Marta Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina  
dc.journal.title
Current Drug Safety  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/15748863113089990035  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/113920/article