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dc.contributor.author
Dučić, Tanja
dc.contributor.author
Alves, Carla S.
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Vučinić, Željko
dc.contributor.author
Lazaro Martinez, Juan Manuel
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dc.contributor.author
Petković, Marijana
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Soto, Juan
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Mutavdžić, Dragosav
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Valle Martínez de Yuso, M.
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Radotić, Ksenija
dc.contributor.author
Algarra, Manuel
dc.date.available
2023-08-18T14:21:00Z
dc.date.issued
2022-10
dc.identifier.citation
Dučić, Tanja; Alves, Carla S.; Vučinić, Željko; Lazaro Martinez, Juan Manuel; Petković, Marijana; et al.; S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach; Academic Press Inc Elsevier Science; Journal of Colloid and Interface Science; 623; 10-2022; 226-237
dc.identifier.issn
0021-9797
dc.identifier.uri
http://hdl.handle.net/11336/208709
dc.description.abstract
S and N-doped carbon dots (S-CDs and N-CDs) and their cisplatin (cis-Pt) derivatives. (S-CDs@cis-Pt and N-CDs@cis-Pt) were tested on two ovarian cancer cell lines: A2780 and A2780 cells resistant to cis-Pt (A2780R). Several spectroscopic techniques were employed to check S-CDs@cis-Pt and N-CDs@cis-Pt: solid- and solution-state nuclear magnetic resonance, matrix-assisted laser desorption, ionization time-of-flight mass spectrometry, and X-ray photoelectron spectroscopy. In addition, synchrotron-based Fourier Transformed Infrared spectro-microscopy was used to evaluate the biochemical changes in cells after treatment with cis-Pt, S-CDs, N-CDs, or S-CDs@cis-Pt and N-CDs@cis-Pt, respectively. Computational chemistry was applied to establish the model for the most stable bond between S-CDs and N-CDs and cis-Pt. The results revealed the successful modification of S-CDs and N-CDs with cis-Pt and the formation of a stable composite system that can be used for drug delivery to cancer cells and likewise to overcome acquired cis-Pt resistance. Nanoparticle treatment of A2780 and A2780R cells led to the changes in their structure of lipids, proteins, and nucleic acids depending on the treatment. The results showed the S-CDs@cis-Pt and N-CDs@cis-Pt might be used in the combination with cis-Pt to treat the adenocarcinoma, thus having a potential to be further developed as drug delivery systems.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CARBON DOTS
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CISPLATIN
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CISPLATIN RESISTANCE
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DRUG DELIVERY
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OVARIAN CANCER
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SPECTROSCOPY
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-07T23:04:15Z
dc.journal.volume
623
dc.journal.pagination
226-237
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Dučić, Tanja. Alba Synchrotron Light Facility; España
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Fil: Alves, Carla S.. Universidade Da Madeira; Portugal
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Fil: Vučinić, Željko. Univerzitet U Beogradu; Serbia
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Fil: Lazaro Martinez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
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Fil: Petković, Marijana. Univerzitet U Beogradu; Serbia
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Fil: Soto, Juan. Universidad de Málaga; España
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Fil: Mutavdžić, Dragosav. Univerzitet U Beogradu; Serbia
dc.description.fil
Fil: Valle Martínez de Yuso, M.. Universidad de Málaga; España
dc.description.fil
Fil: Radotić, Ksenija. Univerzitet U Beogradu; Serbia
dc.description.fil
Fil: Algarra, Manuel. Universidad Pública de Navarra; España
dc.journal.title
Journal of Colloid and Interface Science
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0021979722007858
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jcis.2022.05.005
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