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dc.contributor.author
Martino, Pablo Luis
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dc.contributor.author
Pulopulos, Matias M.
dc.contributor.author
del Canto, Celia Cristina
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dc.contributor.author
Dupanlou, María L.
dc.contributor.author
Rubio, Stella M.
dc.contributor.author
Bonet, José L.
dc.date.available
2023-08-18T13:46:47Z
dc.date.issued
2021-11
dc.identifier.citation
Martino, Pablo Luis; Pulopulos, Matias M.; del Canto, Celia Cristina; Dupanlou, María L.; Rubio, Stella M.; et al.; High levels of TNF-α are associated with symptoms of depression in health professionals at a hospital Altos niveles de TNF-α se asocian a síntomas de depresión en profesionales de la salud de un hospital; Elsevier; Revista de Psiquiatria y Salud Mental; 11-2021; 1-7
dc.identifier.issn
1888-9891
dc.identifier.uri
http://hdl.handle.net/11336/208676
dc.description.abstract
Objective: The current evidence indicates that inflammation is highly related to depression but not to anxiety in clinical samples. However, less understood is the relationship between inflammation and symptoms of depression and anxiety in a nonclinical sample. The aim of this study was to investigate the association between three inflammation markers and symptoms of depression and anxiety in a healthy sample without a history of psychiatric disorders. Methods: Symptoms of depression and anxiety were evaluated in 74 healthy adults (mean age = 42.3; SD = 11.8) using the Hospital Anxiety and Depression Scale. We assessed proinflammatory cytokines (TNF-α, IL-1β, and CRP), and morning cortisol levels using blood samples. Results: TNF-α correlates positively with depressive symptoms, but there were no significant relationships between anxiety scores and inflammation markers. Importantly, TNF-α relates to symptoms of depression independently of anxiety scores, age, body mass index, cortisol, and sex. Conclusions: Our results indicate that TNF-α is associated with depressive symptoms, independently of anxiety, age, body mass index, cortisol, and sex, even in a sample of hospital health professionals without diagnosis or psychiatric history.
dc.format
application/pdf
dc.language.iso
spa
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AFFECTIVE STATE
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NEGATIVE EMOTIONS
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PROINFLAMMATORY CYTOKINES
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PSYCHONEUROIMMUNOLOGY
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TNF-Α
dc.subject.classification
Otras Psicología
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dc.subject.classification
Psicología
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CIENCIAS SOCIALES
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dc.title
High levels of TNF-α are associated with symptoms of depression in health professionals at a hospital Altos niveles de TNF-α se asocian a síntomas de depresión en profesionales de la salud de un hospital
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-08-15T15:25:04Z
dc.identifier.eissn
1989-4600
dc.journal.pagination
1-7
dc.journal.pais
España
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dc.journal.ciudad
Madrid
dc.description.fil
Fil: Martino, Pablo Luis. Universidad Nacional de Rosario. Facultad de Psicología. Secretaria de Ciencia y Tecnología. Centro de Investigación En Neurociencias de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
dc.description.fil
Fil: Pulopulos, Matias M.. Universidad de Zaragoza; España
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Fil: del Canto, Celia Cristina. Gobierno de la Provincia de Mendoza. Hospital Luis Lagomaggiore.; Argentina
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Fil: Dupanlou, María L.. Gobierno de la Provincia de Mendoza. Hospital Luis Lagomaggiore.; Argentina
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Fil: Rubio, Stella M.. No especifíca;
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Fil: Bonet, José L.. Universidad Favaloro; Argentina
dc.journal.title
Revista de Psiquiatria y Salud Mental
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1888989121001221
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.rpsm.2021.10.002
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