Artículo
Galectins: new agonists of platelet activation
Fecha de publicación:
07/2013
Editorial:
De Gruyter
Revista:
Biological Chemistry
ISSN:
1431-6730
e-ISSN:
1437-4315
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several soluble or matricellular proteins can activate platelets. In this article, we review recent advances in knowledge of the role of galectins in platelet physiology. In soluble or immobilized form, these endogenous glycan-binding proteins trigger platelet activation through the modulation of discrete signaling pathways. We discuss the role of platelet–galectin interactions not only in hemostasis, but also in chronic inflammation, atherosclerosis and cancer.
Palabras clave:
Galectins
,
Platelets
,
Hemostasis
,
Atherosclerosis
,
Cancer
,
Inflammation
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Schattner, Mirta Ana; Rabinovich, Gabriel Adrián; Galectins: new agonists of platelet activation; De Gruyter; Biological Chemistry; 394; 7; 7-2013; 1-16
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