A three miRNA-classifier as a new prognostic tool in mycosis fungoides

Abstract

Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL), corresponding approximately 50% of all lymphomas originated in the skin (1). The disease commonly presents an indolent clinical course but some patients progress to more advanced stages with an aggressive behavior. Different studies have provided information in the comprehension of the molecular pathogenesis of MF and identified probable prognostic markers some of them possible targets for future therapeutic intervention (2-5). Interestingly, patients with genomic imbalances have shown shorter overall survival, supporting an association of genomic instability and worse clinical outcome. However, genetic aberrations did not appear to be sufficient to explain the molecular complexity of MF biology and epigenetic changes emerge as another important factor.