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dc.contributor.author
Castro, Gabriela Tatiana
dc.contributor.author
Loyola, Juan Martin
dc.contributor.author
Gasull, Estela Isabel
dc.contributor.author
Almandoz, Maria Cristina
dc.date.available
2023-08-16T18:22:50Z
dc.date.issued
2022-05
dc.identifier.citation
Castro, Gabriela Tatiana; Loyola, Juan Martin; Gasull, Estela Isabel; Almandoz, Maria Cristina; Solubility of meloxicam in ethylene glycol-water and propylene glycol-ethanol mixtures: Experimental determination and thermodynamic analysis; Elsevier Science; Journal of Molecular Liquids; 354; 118863; 5-2022; 1-9
dc.identifier.issn
0167-7322
dc.identifier.uri
http://hdl.handle.net/11336/208499
dc.description.abstract
The solubility profile of meloxicam in ethylene glycol (EG)-water and propylene glycol (PG)–ethanol mixtures at five temperatures in the range of 288.15–308.15 K under atmospheric pressure are determined and related by means of the Jouyban-Acree model. Experimental results show that solubility always increases as temperature increases; and, when the composition of ethylene glycol increased in the first mixture, while in the second one is maximum, in the region 0.4 < XPG < 0.8. The thermodynamic parameters (Gibbs energy, enthalpy and entropy) of meloxicam in both systems are also calculated by using vańt Hoff and Gibbs equations. Both Gibbs energy and enthalpy of solution are positive in the mixture under analysis. As far as, dissolution entropy is negative in all proportion of EG except for neat ethanol; in PG mixture is positive when 0.1 > XPG and the range 0.4 < XPG < 0.6. For ethylene glycol–water mixtures, enthalpy-driving is the main contributing force to the Gibbs energy. Conversely, in propylene glycol systems, the entropic contribution is higher.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ETHYLENE GLYCOL–WATER AND PROPYLENE GLYCOL-ETHANOL MIXTURES
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JOUYBAN–ACREE MODEL
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MELOXICAM
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SOLUBILITY
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THERMODYNAMIC ANALYSIS
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Físico-Química, Ciencia de los Polímeros, Electroquímica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Solubility of meloxicam in ethylene glycol-water and propylene glycol-ethanol mixtures: Experimental determination and thermodynamic analysis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-07-18T15:17:32Z
dc.journal.volume
354
dc.journal.number
118863
dc.journal.pagination
1-9
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Castro, Gabriela Tatiana. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina
dc.description.fil
Fil: Loyola, Juan Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; Argentina
dc.description.fil
Fil: Gasull, Estela Isabel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina
dc.description.fil
Fil: Almandoz, Maria Cristina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química; Argentina
dc.journal.title
Journal of Molecular Liquids
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.molliq.2022.118863
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0167732222004019
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