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dc.contributor.author
Chisari, Andrea Nancy
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dc.contributor.author
Golán, Irene
dc.contributor.author
Campisano, Sabrina Edith
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dc.contributor.author
Gélabert, Caroline
dc.contributor.author
Moustakas, Aristidis
dc.contributor.author
Sancho, Patricia
dc.contributor.author
Caja, Laia
dc.date.available
2023-08-15T16:08:58Z
dc.date.issued
2021-09
dc.identifier.citation
Chisari, Andrea Nancy; Golán, Irene; Campisano, Sabrina Edith; Gélabert, Caroline; Moustakas, Aristidis; et al.; Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types; Frontiers Media; Frontiers in Pharmacology; 12; 9-2021; 1-21
dc.identifier.issn
1663-9812
dc.identifier.uri
http://hdl.handle.net/11336/208365
dc.description.abstract
Malignant cells are commonly characterised by being capable of invading tissue, growing self-sufficiently and uncontrollably, being insensitive to apoptosis induction and controlling their environment, for example inducing angiogenesis. Amongst them, a subpopulation of cancer cells, called cancer stem cells (CSCs) shows sustained replicative potential, tumor-initiating properties and chemoresistance. These characteristics make CSCs responsible for therapy resistance, tumor relapse and growth in distant organs, causing metastatic dissemination. For these reasons, eliminating CSCs is necessary in order to achieve long-term survival of cancer patients. New insights in cancer metabolism have revealed that cellular metabolism in tumors is highly heterogeneous and that CSCs show specific metabolic traits supporting their unique functionality. Indeed, CSCs adapt differently to the deprivation of specific nutrients that represent potentially targetable vulnerabilities. This review focuses on three of the most aggressive tumor types: pancreatic ductal adenocarcinoma (PDAC), hepatocellular carcinoma (HCC) and glioblastoma (GBM). The aim is to prove whether CSCs from different tumour types share common metabolic requirements and responses to nutrient starvation, by outlining the diverse roles of glucose and amino acids within tumour cells and in the tumour microenvironment, as well as the consequences of their deprivation. Beyond their role in biosynthesis, they serve as energy sources and help maintain redox balance. In addition, glucose and amino acid derivatives contribute to immune responses linked to tumourigenesis and metastasis. Furthermore, potential metabolic liabilities are identified and discussed as targets for therapeutic intervention.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AMINO ACID
dc.subject
CANCER STEM CELL (CSC)
dc.subject
GBM-GLIOBLASTOMA MULTIFORME
dc.subject
GLUCOSE
dc.subject
HCC-HEPATOCELLULAR CARCINOMA
dc.subject
PDAC-PANCREATIC DUCTAL ADENOCARCINOMA
dc.subject
THERAPY
dc.subject.classification
Oncología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-08-15T12:24:09Z
dc.journal.volume
12
dc.journal.pagination
1-21
dc.journal.pais
Suiza
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dc.journal.ciudad
Lausanne
dc.description.fil
Fil: Chisari, Andrea Nancy. Universidad Nacional de Mar del Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina
dc.description.fil
Fil: Golán, Irene. No especifíca;
dc.description.fil
Fil: Campisano, Sabrina Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata; Argentina
dc.description.fil
Fil: Gélabert, Caroline. No especifíca;
dc.description.fil
Fil: Moustakas, Aristidis. No especifíca;
dc.description.fil
Fil: Sancho, Patricia. Hospital Universitario Miguel Servet; España
dc.description.fil
Fil: Caja, Laia. No especifíca;
dc.journal.title
Frontiers in Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphar.2021.723798/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fphar.2021.723798
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