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dc.contributor.author
Giachetti, Ana
dc.contributor.author
Díaz, María Sol
dc.contributor.author
Boggio, Paula
dc.contributor.author
Posadas Martinez, Maria Lourdes
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dc.date.available
2023-08-15T13:13:19Z
dc.date.issued
2022-12
dc.identifier.citation
Giachetti, Ana; Díaz, María Sol; Boggio, Paula; Posadas Martinez, Maria Lourdes; Early propranolol treatment of infantile hemangiomas improves outcome; Soc Brasileira Dermatologia; Anais Brasileiros de Dermatologia; 98; 3; 12-2022; 310-315
dc.identifier.issn
0365-0596
dc.identifier.uri
http://hdl.handle.net/11336/208286
dc.description.abstract
Background: Infantile hemangiomas (IH) are the most common soft tissue tumors of childhood. Although most of these tumors are not worrisome, some IH may be life or function-threatening, can lead to permanent disfigurement, or have associated structural congenital anomalies, requiring early recognition and referral to specialists for treatment consideration. Since 2008, oral propranolol has been widely considered to be the first-line treatment for IH. Objectives: To evaluate aesthetic and functional outcome in propranolol-treated infantile hemangiomas according to the age of treatment onset. Methods: Retrospective, observational study of infantile hemangioma patients under 4 years of age at the time of diagnosis, treated with oral propranolol. Evaluated parameters included: pre and post-treatment morphologic/aesthetic aspects of the hemangioma, total resolution rate, degree of functional compromise of affected areas and its evolution. Two independent pediatric dermatologists evaluated all cases reviewing clinical data from medical records and comparing clinical photographs taken at initiation and at the end of treatment of each patient. Data were analyzed with STATA 13.0 program. Results: The cohort included 138 patients, with a female predominance. The median age at therapy onset was 3 months. The morphological/aesthetic improvement rate was 99% (95% CI 96‒99), the total resolution rate was 48% (95% CI 44‒60) and the functional improvement rate reached 100%. When comparing total resolution outcome versus age when treatment started, the improvement was larger in younger patients (3.5 vs. 4.9 months, p = 0.01). When comparing the total resolution rate in those younger or older than 3 months at treatment initiation, the percentage of total resolution in the younger group was 57% vs. 40% in the older one (p = 0.05). Study limitations: Retrospective design; patients photographs were the sole indicators used to measure regression rates. Visual assessment is subjective. Conclusion: The present results strongly suggest that early (before 3 months of age) initiation of treatment of infantile hemangiomas with propranolol results in significantly higher aesthetic and functional improvement rates and a higher percentage of total resolution.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Soc Brasileira Dermatologia
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHILD
dc.subject
HEMANGIOMA
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PROPANOLOL/THERAPEUTIC USE
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PROPRANOLOL
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Dermatología y Enfermedades Venéreas
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Early propranolol treatment of infantile hemangiomas improves outcome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-06-16T13:00:34Z
dc.identifier.eissn
1806-4841
dc.journal.volume
98
dc.journal.number
3
dc.journal.pagination
310-315
dc.journal.pais
Brasil
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dc.description.fil
Fil: Giachetti, Ana. Hospital Italiano; Argentina
dc.description.fil
Fil: Díaz, María Sol. Hospital Italiano; Argentina
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Fil: Boggio, Paula. Hospital Italiano; Argentina
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Fil: Posadas Martinez, Maria Lourdes. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Anais Brasileiros de Dermatologia
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0365059622003166
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.abd.2022.04.008
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