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dc.contributor.author
Ziegler, Tatiana Elisa
dc.contributor.author
Molina Alcalá, Antonio
dc.contributor.author
Anaya, Gabriel
dc.contributor.author
Demyda Peyrás, Sebastián
dc.date.available
2023-08-11T13:32:08Z
dc.date.issued
2021
dc.identifier.citation
Extended haplotype homozygosity analysis reveals positive selection patters in 6 Spanish goat breeds; 38th International Society for Animal Genetics Virtual Conference (2021); Estados Unidos; 2021; 137-137
dc.identifier.uri
http://hdl.handle.net/11336/207883
dc.description.abstract
Goats are a major livestock resource in Spain. Their adaptability and resilience in adverse environments and their increased productivity even in intensive schemes make them valuable livestock resources. For this reason, several local breeds were developed, focused on meat or dairyproduction during the last decades. In this study, we determined the presence of selection fingerprints in dairy (n = 2) and meat (n = 3) Spanish goat breeds, by estimating the integrated haplotype score (iHS) of the extended haplotype homozygosity (EHH) analysis using SNP array information. Samples from178 Spanish individuals including 46 Malagueña (MLG), 43 Florida (FLO) and 25 Murciano-Granadina (MUR) dairy goats, and 24 Bermeya (BER), 20 Mallorquina (MLL) y 20 Blanca de la Rasquera (RAS) were genotyped using the Illumina GoatSNP50 BeadChip (55,000markers). Data were pruned by LD and MAF using PLINK and analyzed (per breed) using the REHH package of the statistical environment R. Finally, candidate regions (selection sweeps, SS) were selected based on the iHS P-value with a minimum length of 1Mb. Results showed a clear anddistinctive iHS peak in the CHI12, despite their productive ability. This selective signature, located in a chromosome previously associated with adaptability, could be related to a genetic ability to cope with the Spanish environment, in which all these breeds were bred during the last 50 years, characterized as harsh and with low levels of forage lands. In addition, meat breeds showed an increased number of selective sweeps but more diffuses than dairy breeds (19 vs 11 on average). In particular, the less selected breeds (RAS and MLL) showed more than 20 small selective sweeps located in 15 different chromosomes, whereas the most selected breed (FLO) showed only 8 candidate regions located in 5 different chromosomes, including a clear peak in CHI6. Overall, we demonstrated that iHS could be an interesting tool to analyze differences in adaptability and selection process in Spanish goats. Further research, including functional analysis of the regions detected, is necessary to obtain more precise conclusions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
International Society for Animal Genetics
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GOAT AND RELATED SPECIES
dc.subject
POPULATION GENOMICS
dc.subject
BREED DIVERSITY
dc.subject.classification
Tecnología GM, clonación de ganado, selección asistida, diagnósticos, tecnología de producción de biomasa, etc.
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Biotecnología Agropecuaria
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CIENCIAS AGRÍCOLAS
dc.title
Extended haplotype homozygosity analysis reveals positive selection patters in 6 Spanish goat breeds
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2022-11-09T16:57:02Z
dc.journal.pagination
137-137
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Champaigne
dc.description.fil
Fil: Ziegler, Tatiana Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
dc.description.fil
Fil: Molina Alcalá, Antonio. Universidad de Córdoba; España
dc.description.fil
Fil: Anaya, Gabriel. Universidad de Córdoba; España
dc.description.fil
Fil: Demyda Peyrás, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.isag.us/Docs/Proceedings/ISAG2021_Proceedings.pdf
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.conicet.rol
Autor
dc.coverage
Internacional
dc.type.subtype
Conferencia
dc.description.nombreEvento
38th International Society for Animal Genetics Virtual Conference (2021)
dc.date.evento
2021-07-26
dc.description.paisEvento
Estados Unidos
dc.type.publicacion
Book
dc.description.institucionOrganizadora
International Society for Animal Genetics meeting
dc.source.libro
Abstract: 38th International Society for Animal Genetics Virtual Conference (2021)
dc.date.eventoHasta
2021-07-30
dc.type
Conferencia
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