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dc.contributor.author
D'Atri, Lina Paola
dc.contributor.author
Schattner, Mirta Ana
dc.date.available
2017-07-17T22:32:46Z
dc.date.issued
2017-06
dc.identifier.citation
D'Atri, Lina Paola; Schattner, Mirta Ana; Platelet toll-like receptors in thromboinflammation; Frontiers in Bioscience; Frontiers In Bioscience-landmark; 22; 11; 6-2017; 1867-1883
dc.identifier.issn
1093-9946
dc.identifier.uri
http://hdl.handle.net/11336/20786
dc.description.abstract
Besides their undiscussed role in hemostasis and thrombosis, platelets are also key effector cells capable of assisting and modulating inflammatory reactions and immune responses. Platelets play a sentinel role in immune surveillance by recognizing danger signals from pathogens and cell damage through the expression of toll-like receptors (TLRs) on its surface and internal compartments. Platelets express all 10 TLRs transcripts and its signalosome, including adaptor proteins and transcription factors. The activation of these receptors in platelets triggers hemostatic and inflammatory responses which participate in the host’s response to bacterial and viral infections, linking thrombosis with infection and immunity. Among the responses elicited by the activation of platelet TLRs are platelet adhesion and aggregation, formation of mixed platelet-leukocyte aggregates, expression and secretion of cytokines and quemokines, and thrombin generation. TLRs also are expressed in megakaryocytes, and their activation regulates not only platelet biogenesis, but also pro-inflammatory and antiviral responses. This review will focus on work that has shown the role of platelet TLRs, mainly in thromboinflammatory responses elicited by platelets and megakaryocytes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers in Bioscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Toll Like Receptors
dc.subject
Platelets
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Megakaryocytes
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Thrombosis
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Inflammation
dc.subject
Sepsis
dc.subject.classification
Otras Medicina Básica
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Platelet toll-like receptors in thromboinflammation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-21T16:50:06Z
dc.journal.volume
22
dc.journal.number
11
dc.journal.pagination
1867-1883
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Irvine
dc.description.fil
Fil: D'Atri, Lina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
Frontiers In Bioscience-landmark
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.bioscience.org/2017/v22/af/4576/list.htm
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2741/4576
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