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dc.contributor.author
Aarsetøy, Reidun
dc.contributor.author
Ueland, Thor
dc.contributor.author
Aukrust, Pål
dc.contributor.author
Michelsen, Annika E.
dc.contributor.author
Leon de la Fuente, Ricardo Alfonso
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dc.contributor.author
Pönitz, Volker
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Brügger-Andersen, Trygve
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Grundt, Heidi
dc.contributor.author
Staines, Harry
dc.contributor.author
Nilsen, Dennis W. T.
dc.date.available
2023-08-11T12:12:20Z
dc.date.issued
2021-10
dc.identifier.citation
Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika E.; Leon de la Fuente, Ricardo Alfonso; et al.; Angiopoietin-2 and angiopoietin-like 4 protein provide prognostic information in patients with suspected acute coronary syndrome; Wiley Blackwell Publishing, Inc; Journal Of Internal Medicine; 290; 4; 10-2021; 894-909
dc.identifier.issn
0954-6820
dc.identifier.uri
http://hdl.handle.net/11336/207864
dc.description.abstract
Background: Plasma levels of angiopoietin-2 (ANGPT2) and angiopoietin-like 4 protein (ANGPTL4) reflect different pathophysiological aspects of cardiovascular disease. We evaluated their association with outcome in a hospitalized Norwegian patient cohort (n = 871) with suspected acute coronary syndrome (ACS) and validated our results in a similar Argentinean cohort (n = 982). Methods: A cox regression model, adjusting for traditional cardiovascular risk factors, was fitted for ANGPT2 and ANGPTL4, respectively, with all-cause mortality and cardiac death within 24 months and all-cause mortality within 60 months as the dependent variables. Results: At 24 months follow-up, 138 (15.8%) of the Norwegian and 119 (12.1%) of the Argentinian cohort had died, of which 86 and 66 deaths, respectively, were classified as cardiac. At 60 months, a total of 259 (29.7%) and 173 (17.6%) patients, respectively, had died. ANGPT2 was independently associated with all-cause mortality in both cohorts at 24 months [hazard ratio (HR) 1.27 (95% confidence interval (CI), 1.08–1.50) for Norway, and HR 1.57 (95% CI, 1.27–1.95) for Argentina], with similar results at 60 months [HR 1.19 (95% CI, 1.05–1.35) (Norway), and HR 1.56 (95% CI, 1.30–1.88) (Argentina)], and was also significantly associated with cardiac death [HR 1.51 (95% CI, 1.14–2.00)], in the Argentinean population. ANGPTL4 was significantly associated with all-cause mortality in the Argentinean cohort at 24 months [HR 1.39 (95% CI, 1.15–1.68)] and at 60 months [HR 1.43 (95% CI, 1.23–1.67)], enforcing trends in the Norwegian population. Conclusions: ANGPT2 and ANGPTL4 were significantly associated with outcome in similar ACS patient cohorts recruited on two continents.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ACUTE CORONARY SYNDROME
dc.subject
ALL-CAUSE MORTALITY
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ANGIOPOIETIN-2
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ANGIOPOIETIN-LIKE 4 PROTEIN
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CARDIAC DEATH
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PROGNOSTIC BIOMARKERS
dc.subject.classification
Sistemas Cardíaco y Cardiovascular
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Angiopoietin-2 and angiopoietin-like 4 protein provide prognostic information in patients with suspected acute coronary syndrome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-08-10T17:52:32Z
dc.journal.volume
290
dc.journal.number
4
dc.journal.pagination
894-909
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Aarsetøy, Reidun. University of Bergen; Noruega
dc.description.fil
Fil: Ueland, Thor. Oslo University Hospital; Noruega
dc.description.fil
Fil: Aukrust, Pål. Oslo University Hospital; Noruega
dc.description.fil
Fil: Michelsen, Annika E.. Oslo University Hospital; Noruega
dc.description.fil
Fil: Leon de la Fuente, Ricardo Alfonso. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Pönitz, Volker. Stavanger University Hospital; Noruega
dc.description.fil
Fil: Brügger-Andersen, Trygve. Stavanger University Hospital; Noruega
dc.description.fil
Fil: Grundt, Heidi. University of Bergen; Noruega
dc.description.fil
Fil: Staines, Harry. No especifíca;
dc.description.fil
Fil: Nilsen, Dennis W. T.. University of Bergen; Noruega
dc.journal.title
Journal Of Internal Medicine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/joim.13339
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