Artículo
Antioxidant and Anticancer Activities and Protein Interaction of the Oxidovanadium(IV) Naringin Complex
Restrepo Guerrero, Andrés Gonzalo
; Goitia Semenco, Helen; Naso, Luciana Gissella
; Rey, Marilin; González, Pablo Javier
; Ferrer, Evelina Gloria
; Williams, Patricia Ana María
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
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Fecha de publicación:
01/2022
Editorial:
MDPI
Revista:
Inorganics
ISSN:
2304-6740
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The complex of oxidovanadium(IV) with naringin (Narg) [VO(Narg)2 ] 8H2 O (VONarg) was prepared according to the literature improving the synthetic procedure and physicochemical characterization. In addition, biological activities (cytotoxic, antioxidant, and BSA interaction) were determined. The metal coordinated through the 5-hydroxy and 4-carbonyl groups of rings A and C of naringin, respectively. The antioxidant activity of VONarg, determined in vitro, was higher than those of the flavonoid against superoxide and peroxyl reactive oxygen species (ROS) and DPPH radical. The cytotoxic properties were determined by a MTT assay on adenocarcinoma human alveolar basal epithelial cells (A549). VONarg exerted a 20% decrease in cancer cells viability at 24 h incubation, while naringin and oxidovanadium(IV) cation did not show cytotoxicity. Measurements with the normal HEK293 cell line showed that the inhibitory action of the complex is selective. VONarg generated intracellular reactive oxygen species (ROS), depletion of reduced glutathione and depolarization of mitochondrial membrane potential, typical for apoptotic pathway, producing cell death by oxidative stress mechanism. Moreover, naringin interacted with bovine serum albumin (BSA) through hydrophobic interactions in a spontaneous process, and VONarg showed greater affinity for the protein but can still be transported and delivered by it (Ka 104 L·mol−1 order).
Palabras clave:
ANTIOXIDANT
,
ANTITUMORAL
,
GLYCOSYLATED FLAVONOID
,
OXIDOVANADIUM(IV) COMPLEX
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Licencia
Identificadores
Colecciones
Articulos(CCT - SANTA FE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Articulos(CEQUINOR)
Articulos de CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Articulos de CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Citación
Restrepo Guerrero, Andrés Gonzalo; Goitia Semenco, Helen; Naso, Luciana Gissella; Rey, Marilin; González, Pablo Javier; et al.; Antioxidant and Anticancer Activities and Protein Interaction of the Oxidovanadium(IV) Naringin Complex; MDPI; Inorganics; 10; 1; 1-2022; 1-19
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