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dc.contributor.author
Caimi, Ayelen Tatiana  
dc.contributor.author
Yasynska, Olena  
dc.contributor.author
Rivas Rojas, Patricia Carolina  
dc.contributor.author
Romero, Eder Lilia  
dc.contributor.author
Morilla, María José  
dc.date.available
2023-08-07T18:56:21Z  
dc.date.issued
2022-11  
dc.identifier.citation
Caimi, Ayelen Tatiana; Yasynska, Olena; Rivas Rojas, Patricia Carolina; Romero, Eder Lilia; Morilla, María José; Improved stability and biological activity of bacterioruberin in nanovesicles; Elsevier; Journal of Drug Delivery Science and Technology; 77; 11-2022; 1-11  
dc.identifier.issn
1773-2247  
dc.identifier.uri
http://hdl.handle.net/11336/207275  
dc.description.abstract
Bacterioruberin (BR) is a dipolar C50 isoprenoid with 13 conjugated double bonds and four terminals hydroxyl groups produced by most members of the Haloferacaceae family of halophilic archaea. BR is a natural antioxidant with antimicrobial, antiviral, anticancer and antihaemolytic activity, but its chemical lability, poor water solubility and low bioavailability spoil many of its potential therapeutic uses. In this work, BR extracted from Halorubrum tebenquichense was loaded into liposomes (L-BR, soybean phosphatidylcholine) and archaeosomes (A-BR, sn 2,3 ether-linked archaeolipids). A-BR (125 nm; −50 mV ζ potential, 9.6 μg BR/mg lipids) preserved the antioxidant activity of BR in front of light and temperature, protected its structure against acidity and retained BR within archaeolipid bilayers for 2 years. In contrast, L-BR (154 nm; −13 mV ζ potential, 6.9 μg BR/mg lipids) failed to protect and retain BR. Besides, A-BR inhibited haemolysis induced by ROO* and was more captured by macrophages (J774A.1 cells) than L-BR. However, the anti-inflammatory (TNF-α release) and antioxidant activities (ROS reduction) from A-BR on lipopolysaccharide or H2O2-stimulated J774A.1 cells were comparable to those from L-BR. BR partitioned both in A and L, but SAXS analysis suggested that only archaeosomes mechanically trapped BR, making its partition more stable than in liposomal bilayers, and this impairs its intracytoplasmic delivery. Results postulate A-BR as a candidate for future investigations in chronic inflammatory diseases.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ARCHAEOLIPIDS  
dc.subject
BACTERIORUBERIN  
dc.subject
CHRONIC INFLAMMATORY DISEASES  
dc.subject.classification
Otras Nanotecnología  
dc.subject.classification
Nanotecnología  
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Improved stability and biological activity of bacterioruberin in nanovesicles  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-07-28T17:28:00Z  
dc.journal.volume
77  
dc.journal.pagination
1-11  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Caimi, Ayelen Tatiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Diseño de Estrategias de Targeting de Drogas; Argentina  
dc.description.fil
Fil: Yasynska, Olena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Diseño de Estrategias de Targeting de Drogas; Argentina  
dc.description.fil
Fil: Rivas Rojas, Patricia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina  
dc.description.fil
Fil: Romero, Eder Lilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Diseño de Estrategias de Targeting de Drogas; Argentina  
dc.description.fil
Fil: Morilla, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Diseño de Estrategias de Targeting de Drogas; Argentina  
dc.journal.title
Journal of Drug Delivery Science and Technology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1773224722008073  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.jddst.2022.103896